Reiter's Syndrome Associated with HLA-B51

概要

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A 22-year-old Japanese man developed polyarthritis with fever and urethritis. He was diagnosed as Reiters syndrome since he was found to have uveitis and persistent aseptic pyuria. Although, he was negative for HL A-B27 or any other HLA-B27 cross-reactive MHC class I antigens, he was positive for HLA-B51. The laboratory examination showed significant elevation of serum IgG and IgA anti-Chlamydia antibodies. He was successfully treated with a combination of doxycycline, naproxen, salazosulfapyridine and methotrexate with a decrease in IgG and IgA anti-Chlamydia antibodies. Previous studies provided evidence that HLA-B51 itself might be involved in the development of Behçets disease, which shares common features with Reiters syndrome, such as uveitis, skin lesions, and polyarthritis. It is therefore suggested that combination of Chlamydia infection and HLA-B51 might play a role in the pathogenesis of Reiters syndrome in our patient.(Internal Medicine 39: 182-184, 2000)
社団法人日本内科学会の論文
2000-02-01