Changes in Biomarkers Focused on Differences in Disease Course or Treatment in Patients with Neuro-Behçet's Disease
スポンサーリンク
概要
- 論文の詳細を見る
Objective Neurological manifestations of Behçet's disease (NB) are serious complications. However, their pathogenesis remains unclear. The current study examined the levels of proinflammatory cytokines, including IL-1β, IL-6, IL-8 and TNF-α, in cerebrospinal fluid (CSF). Methods CSF cytokines were measured using an enzyme-linked immunosorbent assay. CSF was obtained from 17 patients with acute NB, 19 patients with chronic progressive NB and 20 patients with non-inflammatory neurological diseases, including cerebrovascular disease, cervical spondylosis and degenerative diseases. Results CSF total cell counts and polymorph nuclear leukocyte counts were significantly lower in the patients with chronic progressive NB than in those with acute NB. The CSF levels of IL-6 and IL-8 were markedly elevated in the NB patients compared with those measured in the control patients. There were no significant differences in the CSF levels of IL-6 and IL-8 between the patients with acute NB and those with chronic progressive NB. In contrast, there were no significant differences in the CSF levels of IL-1β and TNF-α among the control, acute NB and chronic progressive NB patients. Consistently, the CSF levels of IL-6 and IL-8 were significantly decreased following successful treatment in both acute NB and chronic progressive NB patients, whereas the CSF levels of IL-1β and TNF-α were not changed significantly. Of note, the CSF levels of IL-6 were significantly correlated with the CSF levels of IL-8 in the patients with acute NB (r =0.7647, p =0.0003) but not in the patients with chronic progressive NB (r =0.1343, p =0.5835). Conclusion These results indicate that CSF IL-6 and IL-8 play important roles in the pathogenesis of NB. However, the data also suggest that the mechanisms underlying the elevation of CSF IL-6 and IL-8 might be different in patients with acute NB and those with chronic progressive NB.
- 社団法人 日本内科学会の論文
著者
-
Kikuchi Hirotoshi
Department Of Internal Medicine Teikyo University School Of Medicine
-
Hirohata Shunsei
Department Of Internal Medicine Teikyo University
-
Kikuchi Hirotoshi
Department of Internal Medicine, Teikyo University School of Medicine, Japan
-
Hirohata Shunsei
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Japan
関連論文
- Possible Physiological Roles of Proteolytic Products of Actin in Neutrophils of Patients with Behcet's Disease
- Characterization of a Protease Responsible for Truncated Actin Increase in Neutrophils of Patients with Behcet's Disease
- Analysis of Neutrophil Proteins of Patients with Behcet's Disease by Two-Dimensional Gel Electrophoresis
- HLA-B51 and cigarette smoking as risk factors for chronic progressive neurological manifestations in Behcet's disease
- Congestive heart failure and axonal polyneuropathy induced by alfacalcidol in a patient with systemic lupus erythematosus
- An attack of acute neuro-Behcet's disease during the course of chronic progressive neuro-Behcet's disease : report of two cases
- Reiter's Syndrome Associated with HLA-B51
- Anti-ribosomal P protein antibody induces Th1 responses by enhancing the production of IL-12 in activated monocytes
- Anti-ribosomal P antibodies and lupus nephritis
- Histopathological analysis of cerebral hemorrhage in systemic lupus erythematosus complicated with antiphospholipid syndrome
- Etanercept for the treatment of intractable hemophagocytic syndrome with systemic lupus erythematosus
- Churg-Strauss syndrome complicated by central retinal artery occlusion : case report and a review of the literature
- Clinical features of 405 Japanese patients with systemic sclerosis
- Clinical characteristics of neuro-Behcet's disease in Japan : a multicenter retrospective analysis
- Incidence and the Risk Factor of Malignancy in Japanese Patients with Systemic Sclerosis
- Recurrent Helicobacter cinaedi Cellulitis and Bacteremia in a Patient with Systemic Lupus Erythematosus
- Analysis of membrane antigens on neutrophils from patients with sepsis
- Changes in Biomarkers Focused on Differences in Disease Course or Treatment in Patients with Neuro-Behçet's Disease