38 スピロベチバン類の合成研究
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概要
- 論文の詳細を見る
1. A new spiro-annelation reaction-Copper(I) halide-catalyzed decomposition of phenolic α-diazoketones (4) gave spiro[4.5]deca-6,9-diene-2,8-dione (5) in high yield. 2. A unique regio- and stereo-selective reduction of cross-conjugated dienone-The regiospecific metal-ammonia reductions of both cis-2-hydroxy-1,5,5-trimethylspiro[5.5]undec-7,10-dien-9-one (7a) and its metal alkoxides (7b) and (7c) could be achieved as a result of the proximity of the hydroxy-group to afford 2t-hydroxy-1t,5,5-trimethyl-(6rC^7)-spiro[5.5]undec-7-en-9-one (9) in high yield. The reduction of 2-hydroxy-6,10-dimethylspiro[4.5]dec-6,9-dien-8-one (15) gave 2-hydroxy-6,10t-dimethyl-(5rC^1)-spiro[4.5]dec-6-en-8-one (16) as a main product. 3. (±)-Agarospirol (1), (±)-hinesol (2), and (±)-solavetivone (3) were synthesized by a new spiro-annelation reaction and a unique regio- and stereo-selective reduction of the cross-conjugated dienone.
- 天然有機化合物討論会の論文
- 1981-09-10
著者
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山田 稔
Faculty Of Pharmaceutical Sciences Osaka University
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冨田 研一
Faculty of Pharmaceutical Sciences, Osaka University
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藤原 隆二
Faculty of Pharmaceutical Sciences, Osaka University
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岩田 宙造
大阪大学薬学部製薬化学科
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岩田 宙造
阪大薬
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冨田 研一
阪大薬
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藤原 隆二
阪大薬
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符阪 隆文
Faculty of Pharmaceutical Sciences, Osaka University
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井田 泰夫
阪大薬
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宮下 和之
阪大薬
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符阪 隆文
阪大薬
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山田 稔
阪大薬
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井田 泰夫
Faculty Of Pharmaceutical Sciences Osaka University
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宮下 和之
大阪大学大学院薬学研究科
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