NOVEL AND CHIRAL HANTZSCH-TYPE 1,4-DIHYDROPYRIDINES HAVING A p-TOLYLSULFINYL GROUP. SYNTHESIS AND BIOLOGICAL ACTIVITIES AS CALCIUM CHANNEL ANTAGONISTS

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概要

• 論文の詳細を見る

• Both C-4 stereoisomers of novel Hantzch-type 4-aryl- and 4-methyl-1,4-dihydropyridines 3 having a p-tolylsulfinyl group at C-5 were efficiently synthesized in optically pure forms starting from the α-sulfinyl enones 6 which could be easily obtained from (-)-menthyl (S)-p-tolylsulfinate (4). The stereochemistry at C-4 was found to be largely responsible for the biological activities as calcium channel antagonists of these compounds.

• 1995-04-15

著者

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 今西 武

  大阪大学大学院薬学研究科

• 宮下 和之

  Faculty of Pharmaceutical Sciences, Osaka University

• 石野 哲也

  阪大・薬・製薬化学

• Imanishi Takeshi

  Graduate Shool Of Pharmaceutical Sciences Osaka University

• Nishimoto Masahiro

  Faculty Of Pharmaceutical Sciences Osaka University

• 西本 昌弘

  Faculty Of Pharmaceutical Sciences Osaka University

• Obika Satoshi

  Faculty Of Pharmaceutical Sciences Osaka University

• Imamura T

  Faculty Of Pharmaceutical Sciences Osaka University

• Nishimoto M

  Faculty Of Pharmaceutical Sciences Osaka University

• 宮下 和之

  大阪大学大学院薬学研究科

• 石野 哲也

  Faculty of Pharmaceutical Sciences, Osaka University

• 小比賀 聡

  Faculty of Pharmaceutical Sciences, Osaka University

• 小比賀 聡

  Osaka Univ. Osaka Jpn

• 宮下 和之

  Faculty Of Pharmaceutical Sciences Osaka University

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