Octahydro-7 (1H)-quinolones. I. Stereochemistries of Catalytic Hydrogenation of 7-Hydroxyquinoline

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概要

• 論文の詳細を見る

• 7-Hydroxyquinoline (X) was hydrogenated over 5% rhodium on alumina to give the trans-amino-alcohol (XIa) as a main product along with other possible diastereomeric isomers. Separation of four isomers from the row product was achieved after conversion to the N-benzyl derivatives, XIIIa, XIIIb, XIIIc and XIIId. Configurations of them were assigned from chemical and physical evidences. A possible mechanistic pathway to the trans-fused ring system on hydrogenation was also discussed.

• 公益社団法人日本薬学会の論文
• 1977-06-25

著者

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 内田 秀治

  Faculty of Pharmaceutical Sciences, Osaka University

• 百瀬 雄章

  Faculty of Pharmaceutical Sciences, Kinki University

• 内田 秀治

  Faculty Of Pharmaceutical Sciences Osaka University

• 山足 典子

  Faculty of Pharmaceutical Sciences, Osaka University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 山足 典子

  Faculty Of Pharmaceutical Sciences Osaka University

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