Synthetic Studies on Spirovetivane Phytoalexins. II. : Stereoselective Synthesis of (2RS, 5RS, 6SR, 8RS, 10SR)-6-Hydroxymethyl-8-methoxymethoxy-10-methyl-2-pivaloyloxyspiro[4.5]decane

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概要

• 論文の詳細を見る

• (2RS, 5RS, 6SR, 8RS, 10SR)-6-Hydroxymethyl-8-methoxymethoxy-10-methyl-2-pivaloyloxyspiro[4.5]decane (4a), a key intermediate for the synthesis of the spirovetivane sesquiterpenes, i.e.(±)-lubiminol and (±)-oxylubimin, was synthesized. A stereoselective 1,2-reduction of the enone (6) followed by oxygenation of the C_6-methyl group afforded 10. Subsequent hydrogenation of C_6-C_7 double bond in 10 gave 4a exclusively.

• 公益社団法人日本薬学会の論文
• 1988-11-25

著者

• 山田 稔

  Faculty Of Pharmaceutical Sciences Osaka University

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 竹本 佳司

  Faculty Of Pharmaceutical Sciences Osaka University

• 田中 徹明

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  Faculty of Pharmaceutical Sciences, Osaka University

• 内田 秀治

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  阪大院薬

• 田中 徹明

  阪大院薬

• 田中 徹明

  Faculty Of Pharmaceutical Sciences Osaka University

• Tanaka T

  Kvushu Univ. Fukuoka Jpn

• Tanaka T

  Osaka Univ. Osaka Jpn

• Takemoto Yoshiji

  Faculty Of Pharmaceutical Sciences Osaka University

• Takemoto Y

  Graduate School Of Pharmaceutical Sciences Kyoto University

• 岩田 宙造

  Faculty Of Pharmaceutical Sciences Osaka University

• 窪田 均

  Faculty Of Pharmaceutical Sciences Osaka University

• 内田 秀治

  Faculty Of Pharmaceutical Sciences Osaka University

• Imamura T

  Faculty Of Pharmaceutical Sciences Osaka University

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