Octahydro-7 (1H)-quinolones. VII. A Stereoselective Synthesis of cis, trans-Decahydro-3H, 8H-benzo [i, j] quinolizine-3,8-dione

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概要

• 論文の詳細を見る

• The conversion of 1-(3-chloropropyl)-cis-decahydroquinoline-2,7-dione (3) into decahydro-3H, 8H-benzo [i, j] quinolizine-3,8-diones (12a and 12b) was accomplished with retention of the parent stereochemistry. The stereochemistry of the tricyclic system was assigned from chemical and physical evidences. It was postulated that this successful ring closure in the cis ring system resulted from easy fulfilment of the stereoelectronic requirement, for intramolecular alkylation in 3,much reduced as compared to that for N-acrylyl-cis-octahydro-7 (1H)-quinolone (1b).

• 社団法人日本薬学会の論文
• 1979-01-25

著者

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 内田 秀治

  Faculty of Pharmaceutical Sciences, Osaka University

• 百瀬 雄章

  Faculty of Pharmaceutical Sciences, Kinki University

• 百瀬 雄章

  (present Address)faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 内田 秀治

  Faculty Of Pharmaceutical Sciences Osaka University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

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