1,6-Dihydro-3 (2H)-pyridinones. IV. Synthesis of (±)-Tabersonine and (±)-Cleavamine via a Common Intermediate, Ethyl 3-Ethyl-3-hydroxy-1,2,3,6-tetrahydropyridine-1-carboxylate

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概要

• 論文の詳細を見る

• A formal synthesis of (±)-tabersonine (1) and a total synthesis of (±)-cleavamine (2) have been achieved via a common intermediate (6) derived from ethyl 1,6-dihydro-3 (2H)-pyridinone-1-carboxylate (5a). The successful cyclization of the carboxylic acid (20) to the dioxocleavamine (4) is also discussed.

• 公益社団法人日本薬学会の論文
• 1983-04-25

著者

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 八木 典幸

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 中井 章

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 新 広昭

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 新 広昭

  Faculty Of Pharmaceutical Sciences Kanazawa University

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