Synthetic Studies on the Lycopodium Alkaloids. III. Synthesis of a Key Intermediate, Ethyl Octahydro-4aβ-hydroxy-7β-methyl-10-oxo-1H-5,8α-propanoquinoline-1-carbamate, for the Lycopodium Alkaloids

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概要

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• A tricyclic key intermediate (II) for the lycopodine and the lycodine type of alkaloids was synthesized from 9-oxobicyclo (3,3,1) nonene system (IV) by a series of reactions shown in Chart 2. Dehydration of II with strong acid resulted in the rearrangement of carbon skeleton into an enamino-ketone (III). The stereochemistry of stereoselective C_9-alkylation in IV with sulfonium ylid was also discussed.

• 公益社団法人日本薬学会の論文
• 1970-11-25

著者

• 金 相元

  Faculty of Pharmaceutical Sciences, Josai University

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 金 相元

  Faculty Of Pharmaceutical Sciences Josai University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Josai University

• 百瀬 雄章

  Faculty of Pharmaceutical Sciences, Kinki University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Osaka University

• Kim S‐w

  Faculty Of Pharmaceutical Sciences Josai University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

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