Synthetic Studies on Lignans and Related Compounds. I. Synthesis of 1-Hydroxy-3-hydroxymethyl-4-(3,4-dimethoxyphenyl)-6,7-methylenedioxy-2-naphthoic Acid γ-Lactone

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概要

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• Synthesis of 1-hydroxy-3-hydroxymethyl-4-(3,4-dimethoxyphenyl)-6,7-methylenedioxy-2-naphthoic acid γ-lactone (I), the structure assigned to diphyllin by T. Murakami in 1961,was carried out by starting from 3,4-dimethoxy-3', 4'-methylenedioxybenzophenone (III) as shown in Chart 1. Cyclization of benzhydrylsuccinic acid (V) derived from III occurred selectively on the benzene ring bearing no bromo group as expected. Nonidentity of I with diphyllin was confirmed by comparison of melting points, infrared spectra, thin-layer chromatograms and ferric chloride tests.

• 公益社団法人日本薬学会の論文
• 1968-12-25

著者

• 金 相元

  Faculty of Pharmaceutical Sciences, Josai University

• 金 相元

  Faculty Of Pharmaceutical Sciences Josai University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Josai University

• 百瀬 雄章

  Faculty of Pharmaceutical Sciences, Kinki University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Osaka University

• 大川 和夫

  Faculty Of Pharmaceutical Sciences Osaka University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

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