Synthetic Studies on Anthracyclinones. VI. The Friedel-Crafts Condensation between 3-Methoxyphthalic Anhydride and α-Naphthol Derivatives

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概要

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• The Friedel-Crafts condensation of 3-methoxyphthalic anhydride (IV) gave predominantly 3-methoxy-2-aroylbenzoic acid types. On employment of anhydrous aluminum chloride as a condensing agent, this tendency was exclusive. The Grignard reaction of IV also gave a similar result. The boron trioxide catalyzed condensation of 3-hydroxyphthalic anhydride (IVa), on the contrary, gave exclusively 2-hydroxy-6-aroylbenzoic acid types. The structures of the isomeric aroylbenzoic acid derivatives were established by conversion of them into hydroxynaphthacenequinones.

• 公益社団法人日本薬学会の論文
• 1968-07-25

著者

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Josai University

• 伯水 英夫

  大阪大学薬学部

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 伯水 英夫

  Faculty of Pharmaceutical Sciences, Osaka University

• 吉野 悦子

  Faculty of Pharmaceutical Sciences, Osaka University

• 吉野 悦子

  Faculty Of Pharmaceutical Sciences Osaka University

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