Preparations and Stereochemistries of Ethyl 3α- and 3β-Methyl-9-oxobicyclo (3,3,1) nonane-1-carboxylates and Related Compounds

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概要

• 論文の詳細を見る

• The Michael condensation of ethyl 2-oxo-5-methylcyclohexanecarboxylate with acrolein proceeded stereospecifically to afford, upon intramolecular Aldol-type cyclization followed by dehydration, ethyl 3β-methyl-9-oxobicyclo (3,3,1) non-6-ene-1-carboxylate (IV), which was hydrogenated to 3β-methyl-9-oxobicyclo (3,3,1) nonane-1-carboxylate (V). The corresponding 3α-methyl derivative (XIX) was obtained from the Michael adduct of ethyl 2-oxocyclohexanecarboxylate with methacrolein. Configurations and conformations of the compounds prepared were established from the consideration of chemical and NMR evidences.

• 公益社団法人日本薬学会の論文
• 1968-10-25

著者

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Josai University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Osaka University

• 二宮 一弥

  Faculty of Pharmaceutical Sciences, Osaka University

• 今 相元

  Faculty Of Pharmaceutical Sciences Osaka University

• 二宮 一弥

  阪大薬:(現)神戸女子薬科大学

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