Synthetic Studies on Anthracyclinones. IX. Lithiation of N, N-Dimethylnaphthalenemethylamines and a New Synthetic Pathway to 2,3-Naphthalides

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概要

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• Lithiation of ring-methoxylated N, N-dimethylnaphthalenemethylamines was investigated. The lithiation of 4-methoxy-2-naphthalenemethylamine types (XV and XVII) resulted in a selective lithiation on position 3,leading to an efficient method of β, β'-bis-carbon-substitution on the naphthalene or anthracene ring system. As an application, new syntheses of 1-oxygenated 2,3-naphthalides (XXXII, XXXIII, XXXV, and XXXVI) or 5-oxygenated 2,3-naphthalides (XLII) were accomplished via carboxylation of lithio derivatives, quarternarization of the resulting amino acids and subsequent pyrolysis.

• 公益社団法人日本薬学会の論文
• 1971-06-25

著者

• 松本 泰弘

  Faculty Of Pharmaceutical Sciences Osaka University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Josai University

• 百瀬 雄章

  Faculty of Pharmaceutical Sciences, Kinki University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Osaka University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

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