The Crystal Structure of Securinine Hydrobromide Dihydrate and the Molecular Structure of Securinine
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概要
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X-ray crystal structure analysis has been made on the securinine hydrobromide dihydrate, which is monoclinic, with two formula units in a cell of dimensions : α=7.71Å, b=14.83Å, C=7.04Å, and γ=112.13°. The space group is P2_1. The determination of the atomic parameters was carried out by the generalized projection methods. The conclusions may be summed up as follows : The piperidine ring has a skewed boat form, and the diene part is not co-planar. A dihedral angle of about 10°has been found between the plane passing through C2-, C3-, and C3a-atoms and the one involving C3a-, C4-, and C5-atoms. Discussion has been made on the location of the lone electron pair on the nitrogen atom in the free base.
- 公益社団法人日本薬学会の論文
- 1965-06-25
著者
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堀井 善一
Faculty Of Pharmaceutical Sciences Josai University
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城 始勇
Research And Development Division Rigaku Industrial Corporation
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堀井 善一
Faculty Of Pharmaceutical Sciences Osaka University
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城 始勇
Osaka Research Laboratory, Tanabe Seiyaku Co., Ltd.
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