Synthesis of Four Possible Isomers of 9-(Bromomethylene)-1,2,5-trimethylspiro[5.5]undeca-1,7-dien-3-one : Structure Elucidation of a Brominated Rearranged Chamigrane-Type Sesquiterpene

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概要

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• The first total synthesis of (5R^*, 6R^*)- and (5R^*, 6S^*)-9-(bromomethylene)-1,2,5-trimethyl-spiro[5.5]undeca-1,7-dien-3-one (1a and 1b) was achieved stereoselectively. The relative configuration of C-5 and C-6 of the natural product Z-1 was elucidated as 5R^* and 6R^* by comparison with our synthetic samples.

• 公益社団法人日本薬学会の論文
• 1988-08-25

著者

• 岩田 宙造

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  大阪大学薬学部製薬化学科

• 宮下 和之

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  Faculty Of Pharmaceutical Sciences Osaka University

• 秋山 智弘

  Faculty of Pharmaceutical Sciences, Osaka University

• 秋山 智弘

  Faculty Of Pharmaceutical Sciences Osaka University

• 宮下 和之

  大阪大学大学院薬学研究科

• 宮下 和之

  Faculty Of Pharmaceutical Sciences Osaka University

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