Structure of Rutin Pentamethanol
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概要
- 論文の詳細を見る
The crystal structure of rutin, 3-[(6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy]-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one, has been determined by the X-ray diffraction method. The crystals are orthorhombic with a=8.748 (3), b=23.567 (10), c=36.052 (12) Å and the space group is C222_1. The final R value is 0.102 for 1789 observed reflections after full-matrix least-squares refinement. The dihedral angle between the benzopy-ran and the phenyl rings is 19.0 (7)°, and the quercetin and the rutinose portions are linked together with the torsion angles of 114.1 (18)°and 143.1 (15)°, around the C(3)-O(3) and O(3)-C(1') bonds, respectively. There are two kinds of intramolecular hydrogen bonds between the quercetin and glucose moieties. The structure-function relationship of the flavonoids involving rutin as inhibitors of aldose reductase is also discussed.
- 公益社団法人日本薬学会の論文
- 1990-02-25
著者
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冨田 研一
Faculty of Pharmaceutical Sciences, Osaka University
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山縣 ゆり子
Faculty of Pharmaceutical Sciences, Osaka University
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山縣 ゆり子
阪大薬
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山縣 ゆり子
Faculty Of Pharmaceutical Sciences Osaka University
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金 光洙
Faculty of Pharmaceutical Sciences, Osaka University
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金 光洙
Faculty Of Pharmaceutical Sciences Osaka University
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冨田 研一
Faculty Of Pharmaceutical Sciences Osaka University
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