Asymmetric Desymmetrization of Prochiral 1,3-Diols via Diastereoselective C-O Bond Fission of Bicyclic Acetal Using a Chiral Sulfoxide as a Chiral Auxiliary

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概要

• 論文の詳細を見る

• Asymmetric desymmetrization of a prochiral 1,3-diol was established by diastereoselective C-O bond fission of the chiral α-sulfinyl acetal 6. Treatment of 6 with titanium tetrachloride afforded mainly 7a via an oxonium intermediate, while with lithium diisopropylamide 7b was selectively obtained via diastereoselective β-elimination followed by an olefin isomerization.

• 公益社団法人日本薬学会の論文
• 1996-06-15

著者

• 岩田 宙造

  阪大院薬

• Tanaka T

  Kvushu Univ. Fukuoka Jpn

• Tanaka T

  Osaka Univ. Osaka Jpn

• IWATA Chuzo

  Faculty of Pharmaceutical Sciences, Osaka University

• Iwata Chuzo

  Faculty Of Pharmaceutical Sciences Osaka University

• 田中 恒雄

  Department Of Pharmacy Hyogo College Of Medicine

• Tanaka Tetsuaki

  Faculty Of Pharmaceutical Sciences Osaka University

• Murakami Manabu

  Faculty Of Pharmaceutical Sciences Osaka University

• MAEZAKI Naoyoshi

  Faculty of Pharmaceutical Sciences, Osaka University

• SOEJIMA Motohiro

  Faculty of Pharmaceutical Sciences, Osaka University

• IMANISHI Takeshi

  Faculty of Pharmaceutical Sciences, Osaka University

• Soejima Motohiro

  Faculty Of Pharmaceutical Sciences Osaka University

• Maezaki Naoyoshi

  Faculty Of Pharmaceutical Sciences Osaka University

• Imanishi Takeshi

  Faculty Of Pharmaceutical Sciences Osaka University

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