Synthesis of Thiaprostaglandin E_1 Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A series of new thiaprostaglandins, 4-thia-, 5-thia-, 6-thia-and 7-thiaprostaglandin E_1 methyl esters (3b, 4b, 5b, and 6b), was synthesized by a three-component coupling process using a chiral common synthon, (R)-4-tert-butyldimethylsilyloxy-2-cyclopentenone (1). Among these thiaprostaglandins, 7-thiaprostaglandin E_1 methyl ester showed the most potent platelet aggregationinhibiting activity.
- 社団法人日本薬学会の論文
- 1985-05-25
著者
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黒住 精二
帝人生物医学研究所
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羽里 篤夫
帝人生物医学総合研究所
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羽里 篤夫
Institute For Bio-medical Research Teijin Ltd.
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Tanaka T
Kvushu Univ. Fukuoka Jpn
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大津 晶
Institute For Bio-medical Research Teijin Ltd.
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Tanaka T
Osaka Univ. Osaka Jpn
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神本 福吉
Institute For Bio-medical Research Teijin Ltd.
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融 健
Institute For Bio-medical Research Teijin Ltd.
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融 健
帝人生物医学総合研究所
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田中 利男
Institute oor Bio-medical Research, Teijin Ltd.
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渡辺 兼三
Institute for Bio-medical Research, Teijin Ltd.
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坂内 清
Institute for Bio-medical Research, Teijin Ltd.
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岡村 憲明
Institute for Bio-medical Research, Teijin Ltd.
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真鍋 健次
Institute for Bio-medical Research, Teijin Ltd.
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黒住 精二
Institute for Bio-medical Research, Teijin Ltd.
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渡辺 兼三
Institute For Bio-medical Research Teijin Ltd.
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岡村 憲明
Institute For Bio-medical Research Teijin Ltd.
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坂内 清
Institute For Bio-medical Research Teijin Ltd.
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真鍋 健次
帝人株式会社 生物医学総合研究所
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