Development of Cellulose Derivatives as Novel Enteric Coating Agents Soluble at pH 3.5-4.5 and Higher
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概要
- 論文の詳細を見る
Hydroxypropyl methylcellulose (HPMC) was selected as a base polymer to develop novel enteric coating agents for acid protection which can dissolve at pH around 4,and was modified with trimellitic acid or maleic acid at various degrees of substitution. These carboxylic acids have higher dissociation constants and higher solubility in water than the carboxylic acids of existing enteric coating polymers. The synthesized polymers were micronized and dispersed in aqueous medium to determine their pK_a values by potentiometric titration. The pH of dissolution and the water vapor permeability of the cast films prepared from organic solutions were also evaluated. Hydroxypropyl methylcellulose trimellitate (HPMCT) showed good acid resistance, and the pH at which it dissolves can be controlled in the range of pH 3.5 to 4.5 by varying the content of trimellityl groups and the methoxyl substitution of the base polymer.
- 1997-08-15
著者
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Tanaka T
Osaka Univ. Osaka Jpn
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田中 恒雄
Department Of Pharmacy Hyogo College Of Medicine
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Obara Sakae
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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KOKUBO Hiroyasu
Specialty Chemicals Research Center, Shin-Etsu Chemical Co.
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MINEMURA Katsuyoshi
Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd.,
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TANAKA Takashi
Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd.,
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Minemura Katsuyoshi
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Kokubo Hiroyasu
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Tanaka Takashi
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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