Synthesis of 7-Thiaprostaglandin E_1 Congeners : Potent Inhibitors of Platelet Aggregation
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概要
- 論文の詳細を見る
Novel 7-thiaprostaglandin E_1 derivatives and congeners were synthesized by a stepwise three-component coupling process, which involves the introduction of α-side chains (thiols) and β-side chains (organocopper reagents) into (R)-4-tert-butyldimethylsilyloxy-2-cyclopentenone. Several acid derivatives of 7-thiaprostaglandin E_1 were also prepared either by enzymatic or by chemical methods. The stereochemistry of these products was assigned on the basis of the results with chiral protected cyclopentenones and chiral ω-side chains. Some of these 7-thiaprostaglandin E_1 congeners were found to exhibit more potent platelet aggregation-inhibitory activity than PGE_1. The structure-activity relationship of these congeners is discussed.
- 社団法人日本薬学会の論文
- 1985-06-25
著者
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杉浦 聡
Teijin Institute For Bio-medical Research
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黒住 精二
帝人生物医学研究所
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羽里 篤夫
帝人生物医学総合研究所
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羽里 篤夫
Institute For Bio-medical Research Teijin Ltd.
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Tanaka T
Kvushu Univ. Fukuoka Jpn
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Tanaka T
Osaka Univ. Osaka Jpn
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神本 福吉
Institute For Bio-medical Research Teijin Ltd.
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田中 利男
Teijin Institute for Bio-Medical Research
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岡村 憲明
Teijin Institute for Bio-Medical Research
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坂内 清
Teijin Institute for Bio-Medical Research
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羽里 篤夫
Teijin Institute for Bio-Medical Research
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真鍋 健次
Teijin Institute for Bio-Medical Research
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神本 福吉
Teijin Institute for Bio-Medical Research
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黒住 精二
Teijin Institute for Bio-Medical Research
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坂内 清
Institute for Bio-medical Research, Teijin Ltd.
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岡村 憲明
Institute for Bio-medical Research, Teijin Ltd.
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黒住 精二
Institute for Bio-medical Research, Teijin Ltd.
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岡村 憲明
Institute For Bio-medical Research Teijin Ltd.
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坂内 清
Institute For Bio-medical Research Teijin Ltd.
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真鍋 健次
帝人株式会社 生物医学総合研究所
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