LOW ACTIVITY OF ALDEHYDE DEHYDROGENASE (ALDH) IN LIVER OF SUNCUS MURlNUS : POSSIBLE EXPLANATION FOR HIGH SENSITIVITY TO ALCOHOL

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概要

• 論文の詳細を見る

• Suncus murinus (suncus) is an animal species highly sensitive to ethanol (Lin, S.-C., Saito, H., Yohro, T. and Shiga, J., J. Toxicol. Env. Health, 18: 575-587, 1986). To elucidate the mechanism involved in sensitivity to alcohol, we investigated the properties of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the suncus in comparison with the rat. The activities of ALDH in microsomes and mitochondria of suncus livers were lower than those in rat livers, although the activity of cytosolic ADH was not different between the suncus and the rat. We propose that the high sensitivity of the suncus to alcohol can be accounted for, at least in part, by the low activity of ALDH in suncus liver.

• 日本トキシコロジー学会の論文
• 1997-05-25

著者

• KAMATAKI Tetsuya

  Division of Drug Metabolism, Faculty of Pharmaceuti-cal Sciences, Hokkaido University

• Kamataki Tetsuya

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• ITOH Susumu

  Ludwig Institute for Cancer Research, Biomedical Center

• MATSUYAMA Takafumi

  Division of Drug Metabolism, Faculty of Pharmaceutical Sciences Hokkaido University

• Itoh Susumu

  Ludwig Institute For Cancer Research Biomedical Center

• Matsuyama Takafumi

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University

• Kamataki Tetsuya

  北海道大学 薬学研究院

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