Assessment of the Brain Areas Perfused by Superselective Intra-arterial Chemotherapy Using Single Photon Emission Computed Tomography with Technetium-99m-Hexamethyl-propyleneamine Oxime : Technical Note

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概要

• 論文の詳細を見る

• The brain areas perfused by superselective intra-arterial (i.a.) chemotherapy were assessed using single photon emission computed tomography (SPECT) with technetium-99m-hexamethyl-propyleneamine oxime (^<99m>Tc-HMPAO). A superselective catheter was introduced into the anterior, middle, or posterior cerebral artery of patients with malignant glioma for i.a. chemotherapy. ^<99m>Tc-HMPAO was subsequently injected via the same catheter used for chemotherapy, and a higher dose of ^<99m>Tc-HMPAO was injected intravenously to obtain adequate background brain images. (Comparison of the SPECT images with magnetic resonance images could confirm complete perfusion of the tumor tissue. In two patients with malignant glioma, regions of interest were selected in the peritumoral brain area and a reference brain area, and the radioactivity was measured. The concentration of ^<99m>Tc-HMPAO was about 50 times higher in tissue perfused by superselective injection into anterior or middle cerebral artery compared to intravenous injection. ^<99m>Tc-HMPAO SPECT is readily available in many institutions and the information provided is useful for planning more effective and safe i.a. chemotherapy.

• 日本脳神経外科学会の論文
• 1994-12-15

著者

• SATO Akira

  Division of Advanced Surgical Science and Technology, Tohoku University Hospital

• Watanabe Yoshiro

  Division of Cardiology, Juntendo University

• Iwadate Yasuo

  Divisions Of Neurological Surgery Chiba Cancer Center Hospital

• Kobayashi Shigeki

  Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch

• Namba Hiroki

  Divisions Of Neurological Surgery Chiba Cancer Center Hospital

• SUEYOSHI Kanji

  Divisions of Neurological Surgery Chiba Cancer Center Hospital

• Saegusa Takashi

  Division Of Neurosurgery Chiba Cancer Center Hospital

• Kobayashi Shigeki

  Division Of Analytical Chemistry Of Medicines Showa Pharmaceutical University

• Watanabe Yoshiro

  Division Of Neurosurgery Chiba Emergency Medical Center

• Kobayashi Shigeki

  Division Of Neurosurgery Chiba Emergency Medical Center

• Sato Akira

  Division Of Advanced Surgical Science And Technology Tohoku University School Of Medicine

• Sato Akira

  Division Of Neurosurgery Chiba Emergency Medical Center

• Sato Akira

  Division Of Advanced Surgical Science And Technology Tohoku University Graduate School Of Medicine

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