<Originals>Clinical differences between hypoplastic and normocellular or hyperplastic myelodysplastic syndrome
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概要
- 論文の詳細を見る
We studied a type of myelodysplastic syndrome (MDS) characterized by hypoplastic bone marrow. Seven patients studied had hypoplasia of bone marrow. Twenty-one patients had normocellular or hypercellular marrow. Comparisons of clinical features, hematological findings, chromosome analysis, incidence of progression to acute leukemia and survival were made betweeen hypoplastic and normocellular or hyperplastic MDS. The median age of patients was 74 years in the hypoplastic group and 59 years in the normocellular or hyperplastic group. According to the French-American-British (FAB) classification, the hypoplastic disease group included on patient with refractory anemia (RA), five with refractory anemia with excess of blast (RAEB), and one with RAEB in transformation (RAEB-t). Those with normocellular or hypercellular marrow included seven with RA, two with refractory anemia with ringed sideroblasts (RARS), nine with RAEB and three with RAEB-t. Patients with hypoplastic MDS had severe leukopenia and lower hemoglobin levels than did those in the other group. Five patients with hypoplastic MDS had chromosome of bone marrow analyzed, and three (60%) had abnormalities. Among those with normocellular or hyperplastic bone marrow, 17 had analyses, seven (41.2%) of whom had abnormal results. Four patients (57.1%) from the hypoplastic group and four (19.0%) from the normocellular of hyperplastic group suffered transformation to acute leukemia. Mean length of time from diagnosis to transformation to overt leukemia was 29 months for patients in the hypoplastic group, and 11 months for patients in the normocellular or hyperplastic group. Median survival was 25 months for patients in the hypoplastic group, and 9 months for patients in the normocellular or hyperplastic group. Therefore, hypoplastic MDS appears to be a clinicopathological entity separate from normo- or hyperplastic MDS, and is characterized by marrow hypoplasia, severe leukeopnia and anemia and long survival.
- 近畿大学の論文
著者
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Takayama K
Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine
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Tsukasaki Kunihiro
Department Of Internal Medicine Osaka Medical Center For Cancer And Cardiovascular Diseases
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TSUBAKI Kazuo
Third Department of Internal Medicine, Kinki University School of Medicine
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Tsubaki K
Kinki Univ. School Of Medicine Osaka Jpn
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Tsubaki Kazuo
Third Department Of Internal Medicine Kinki University School Of Medicine
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HORIUCHI Atsushi
Third Department of Internal Medicine, Kinki University School of Medicine
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Tsukasaki K
Department Of Internal Medicine Osaka Medical Center For Cancer And Cardiovascular Diseases
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HORIUCHI Atsushi
Semiconductor Leading Edge Technologies, Inc.
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ASHIDA Takashi
Third Department of Internal Medicine, Kinki University School of Medicine
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HAZU Shizuka
Third Department of Internal Medicine, Kinki University School of Medicine
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ISHIKAWA Hiroyuki
Third Department of Internal Medicine, Kinki University School of Medicine
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URASE Fumiaki
Third Department of Internal Medicine, Kinki University School of Medicine
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IRIMAJIRI Kiyohiro
Third Department of Internal Medicine, Kinki University School of Medicine
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Irimajiri K
Kinki University School Of Pharmaceutical Sciences
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Hazu Shizuka
Third Department Of Internal Medicine Kinki University School Of Medicine
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Ashida Takashi
Third Department Of Internal Medicine Kinki University School Of Medicine
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Ashida Takashi
Power Reactor And Nuclear Fuel Development Corp.
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Horiuchi A
The Third Department Of Internal Medicine Kinki University School Of Medicine
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Horiuchi Atsushi
Semiconductor Leading Edge Technologies Inc.
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Horiuchi Atsushi
Third Department Of Internal Medicine Kinki University School Of Medicine
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Urase Fumiaki
Third Department Of Internal Medicine Kinki University School Of Medicine
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Horiuchi Atsushi
Third Department Of Internai Medicine Kinki University Sohool Of Medicine
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Ishikawa Hiroyuki
Third Department Of Internal Medicine Kinki University School Of Medicine
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Tsukasaki Kunihiro
The Department Of Haematology Of Atomic Disease Institute Nagasaki University School Of Medicine
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