<Originals>Residual Renal Function and Urinary Excretion Substrate by Loop Diuretics Infusion Test in the Patients with Renal Failure

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For the purpose of confirming the initiation time and administration method of loop diuretics in the patients with renal failure, the urinary volume and urinary excretion substrate before and after intravenous injection of Bumetanide 0.025 mg/kg were investigated in 31 cases whose endogenous creatinine clearance (Ccr) was less than 30 ml/min. The urinary volume determined by minute after intravenous injection of Bumetanide, indicated a maximum diuresis taking place during the first 30 minutes in 77% of all the cases, with the urinary volume increasing by 25-400% compared with the control volume. In 95% of the cases, the diuretic effect by Bumetanide was found to be continuing for more than 3 hours. Urinary excretion of creatinine (Cr) and urea nitrogen (UN) was correlated with the urinary volume in the cases with higher Ccr. Urinary excretion of uric acid (UA) was not correlated with the urinary volume in the cases with Ccr of less than 20 ml/min. Urinary excretion of sodium showed a more remarkable correlation with the urinary volume in the cases with higher Ccr, while urinary excretion of potassium had no correlation in the cases with Ccr of less than 20 ml/min, and there was no correlation between calcium or phosphorus and urinary volume either. It is desirable that the administration of loop diuretics should be instituted when Ccr becomes less than 20 ml/min, while therapeutic precautions are needed for hyponatremia and hyperuricemia in the patients with Ccr of 10-20 ml/min, and for hyponatremia, hyperuricemia and hyperkalemia in the cases with less than 10 ml/min. Cases showing Ccr of less than 8 ml/min for 30 minutes after intravenous injection of loop diuretics needed dialysis treatment. In the cases of 5 ml/min the urinary volume was rapidly decreased after introduction of dialysis treatment.
近畿大学の論文
1982-06-25

<Originals>Residual Renal Function and Urinary Excretion Substrate by Loop Diuretics Infusion Test in the Patients with Renal Failure

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