<Reviews>Conception of Immunotherapy for Residual Leukemia Cells

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Due to the progress of chemotherapy for leukemia, the rate of complete remission was increased and the survival time was prolonged, but very few cases have been actually cured. This is explained by the presence of residual leukemia cells even at the stage of complete remission. Since it is not possible to completely eliminate these residual cells, the residual leukemia cells start to proliferate. Complete elimination of these residual leukemia cells is too difficult for the current chemotherapy. In order to solve this problem, the authors have thought that immuno-therapy is a promising candidate. As a basic experiment, cytotoxic cells were generated against autologous leukemia cells in vitro. The type of leukemia cells against which cytotoxic cells were favorably generated was studied and the cytotoxic cells thus generated were characterized. By the treatment of target cells and stimulators with neuraminidase, cytotoxic cells were generated against autologous leukemia cells in 9 of 10 patients with acute leukemia. Against leukemia cells negative Ia antigen, the generation of cytotoxic cells was difficult. When the target cells were treated with Ia antibody, the cytotoxicity against autologous leukemia cells was decreased, but the cytotoxicity against allogeneic leukemia cells did not decrease. The cytotoxic cells generated in this experimental system are characterized by the mixed presence of two populations, lymphocytes with OKT3^+, 11^+, 8^+, and Ia^+ and NK cells. Another possibility is the presence of one population of cells with markers of T cell series and NK cells.
近畿大学の論文
1984-12-28

<Reviews>Conception of Immunotherapy for Residual Leukemia Cells

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