IMMUNOTOXIC EFFECT OF LOW DOSE CISPLATIN IN MICE
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概要
- 論文の詳細を見る
The immunosuppressive effects of cisplatin at relatively low doses were investigated in CD-1 mice. Mice were injected intraperitoneally with 8, 40 and 200 μg/kg cisplatin for 10 days. A decrease in body and thymus weights was observed at 200 μg/kg. Though there were no dose-related effects on the IgM antibody response to sheep erythrocytcs, a statistically significant reduction of the contact hypersensitivity response (CHR) was seen at 200 μg/kg. In vivo and in vitro effects of cisplatin on T- and B-lymphocyte function were assessed by proliferative response to concanavalin A and lipopolysaccharide, respectively. Cisplatin inhibited splenic T-lymphocyte function more than splenic B-lymphocyte function. These data indicate that a relatively low dose of cisplatin induce immunosuppressive effects in mice with a greater effect on T-lymphocytes than the B-lymphocytes.
- 日本トキシコロジー学会の論文
- 1996-11-25
著者
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Maeda Yasuhiro
Third Department Of Internal Medicine Kinki University School Of Medicine
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Maeda Yasuhiro
近畿大学 第3内科
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YAMAMURA Masaomi
Nagasaki CML Study Group
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OHUCHIDA Akinobu
Drug Safety Laboratory, Taiho Pharmaceutical Co. Ltd.
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Ohuchida Akinobu
大鵬薬品工業
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Ohuchida A
Taiho Pharmaceutical Co. Ltd. Tokushima Jpn
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Ohuchida Akinobu
Drug Safety Research Laboratory Taiho Pharmaceutical Co. Ltd.
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Ohuchida Akinobu
Drug Safetey Lab. Taiho Pharmaceutical Co. Ltd.
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Maeda Yasuhiro
Department Of Hematology Nephrology And Clinical Immunology Kinki University School Of Medicine
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KOUCHI Yasuhide
Drug Safety Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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MAEDA Yasuhiro
Drug Safety Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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OHSAWA Motoyasu
Department of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University
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Morita Yasuyoshi
Third Department Of Internal Medicine Kinki University School Of Medicine
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Maeda Yasuhiro
Drug Safety Research Laboratory Taiho Pharmaceutical Co. Ltd.
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Ohsawa M
Teikyo Univ. Kanagawa Jpn
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Ohsawa Motoyasu
Department Of Enviromnental Toxicology Faculty Of Pharmaceutical Sciences Teikyo University
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Miyazaki Yasushi
Department Of Hematology Tama Hokubu Medical Center
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Maeda Yasuhiro
Department Of Applied Physics Tokyo Institute Of Technology
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