Temporal Changes in Erectile Function and Endothelium-Dependent Relaxing Response of Corpus Cavernosal Smooth Muscle After Ischemia by Ligation of Bilateral Internal Iliac Arteries in the Rabbit
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概要
- 論文の詳細を見る
We aimed to elucidate the changes in the relaxation function of corpus cavernosal smooth muscle (CCSM) and erectile function using acute penile ischemic rabbits. Relaxation response to acetylcholine (Ach) was unchanged at 3 days after ischemia. The response to ACh had significantly decreased at 1 week, but had recovered completely at 4 weeks. The reaction to sodium nitroprusside and electrical field stimulation was unchanged by ischemia at all time points. Erectile function was changed in the same manner as the response of ACh. The endothelium-dependent relaxing responses of CCSM and erectile function were found to be initially decreased, but subsequently improved completely.
著者
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Hotta Yuji
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Abe Yuko
Department Of Cellular Life Science Faculty Of Advanced Life Science Hokkaido University
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Maeda Yasuhiro
Department Of Applied Physics Tokyo Institute Of Technology
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Abe Yuko
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Kimura Kazunori
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Okumura Kana
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Kataoka Tomoya
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Hotta Yuji
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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MAEDA Yasuhiro
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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Maeda Yasuhiro
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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KIMURA Kazunori
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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