MUTAGENICITY TEST OF CEFODIZIME SODIUM
スポンサーリンク
概要
- 論文の詳細を見る
The mutagenicity of cefodizime sodium (THR-221) was investigated by the reverse mutation test using seven bacterial strains (Salmonella typhi-murium strains TA100, TA98, TA1535, TA1537 and TA1538, and Echerichia coli strains WP2 and WP2uvrA) and the chromosomal aberration test with cultured Chinese hamster lung (CHL) cells. The reverse mutation test was carried out in dose range from 0.0025 to 5.0 μg/plate in the absence and presence of mammalian metabolic activation system. Antibacterial effects were observed at concentrations more than 0.25 μg/plate, and no significant increases in the number of revertants were observed at the dose levels where antibacterial effects were not detected. THR-221 caused no increases in the number of chromosomal aberrants at dose levels of 0.75, 1.5, 3.0 and 6.0 mg/ml in the absence and presence of the metabolic activation. These results indicate that THR-221 has no mutagenic activity.
- 日本トキシコロジー学会の論文
- 1988-06-03
著者
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OHUCHIDA Akinobu
Drug Safety Laboratory, Taiho Pharmaceutical Co. Ltd.
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Ohuchida Akinobu
大鵬薬品工業
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Ohuchida A
Taiho Pharmaceutical Co. Ltd. Tokushima Jpn
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Ohuchida Akinobu
Drug Safety Research Laboratory Taiho Pharmaceutical Co. Ltd.
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Ohuchida Akinobu
Drug Safetey Lab. Taiho Pharmaceutical Co. Ltd.
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YOSHIDA Ryouichi
Drug Safety Laboratory, Taiho Pharmaceutical Co., Ltd.
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Yoshida R
Taiho Pharmaceutical Co. Ltd. Tokushima Jpn
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Yoshida Ryouichi
Drug Safety Laboratory Taiho Pharmaceutical Co. Ltd.
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