<Originals>Superoxide dismutase and nitric oxide synthase activities in SHRSP cerebral cortex and hippocampus
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概要
- 論文の詳細を見る
Mn-, Cu/Zn-superoxide dismutase (SOD) and constitutive type of nitric oxide synthase (NOS) activities in the brain were determined in stroke-prone spontaneously hypertensive rats (SHRSP). Results were compared to Wistar Kyoto rats (WKY) to determine the levels of protection against oxidative stress. In the hippocampus, Mn-, and Cu/Zn-SOD activities in 31-week-old SHRSP were significantly lower than in 15-week-old or WKY. NOS activity in the hippocampus showed no difference between SHRSP and WKY. In the 31-week-old SHRSP cerebral cortex, cerebral injuries occurred and the activities of Mn- and Cu/Zn-SOD and NOS were significantly lower than in 15-week-old or WKY. These observations indicated that hypertensive vascular disease observed in the SHRSP cerebral cortex was a result of decreased antioxidant capacity which is closely associated with the development of stroke and, in turn, shortened life span.
- 近畿大学の論文
著者
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Tomura Takanori
Department of Biochemistry, Kinki University School of Medicine
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IRIMAJIRI Kiyohiro
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Kinki University
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Irimajiri K
Kinki University School Of Pharmaceutical Sciences
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Irimajiri Kiyohiro
Department Of Pharmacotherapy Faculty Of Pharmaceutical Sciences Kinki University
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Nishida S
Kinki University School Of Pharmaceutical Sciences
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Nishida Shozo
Department Of Ophthalmology Nagoya City University Medical School
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Nishida Shozo
Department Of Ophthalmology Aichi Medical University
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Tomura Takanori
Department Of Biochemistry & Oncology Kinki University School Of Medicine
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HAGA Hisae
Kinki University School of Pharmaceutical Sciences
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KIMOTO-KINOSHITA Saori
Department of Biochemistry & Oncology, Kinki University School of Medicine
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HAGA Hisae
Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Kinki University
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Kikuichi S
Kinki Univ. School Of Pharmaceutical Sci. Osaka Jpn
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