<Originals>Combination of exonucleolytic and polymerase activities in a purified rat liver enzyme

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概要

• 論文の詳細を見る

• In bacteria, in vitro repair of thymine dimers can be achieved by the sequential action of a Micrococcus luteus endonuclease and DNA polymerase I. The repair activity of DNA polymerase I is associated with its 5'→3' exonucleolytic activity. DNA polymerase activities were purified from rat liver. Partially purified enzyme was passed through a DNA cellulose column. The DNA has previously been nicked with a repair endonuclease purified from rat liver. Three fractions were obtained. The fractions were then eluted on a SDS Sephadex G200 column. The first fraction (170,000 daltons) has only DNA polymerase activity, the second (40,000 daltons) has both 5'→3' exonuclease and DNA polymerase activity. The third fraction (18,000 to 20,000 daltons) has only exonucleolytic activity. The second fraction was recovered with both polymerase and exonuclease activities.

• 近畿大学の論文

著者

• Tomura Takanori

  Department of Biochemistry, Kinki University School of Medicine

• Van Lancker

  Departments Of Pathology And Radiation Oncology Ucla Center For The Health Sciences

• Tomura T

  Kinki Univ. School Of Medicine Osaka Jpn

• Tomura Takanori

  Department Of Biochemistry & Oncology Kinki University School Of Medicine

• SUEYOSHI Akihiro

  Department of Pathology and Radiation Oncology, UCLA Center for the Health Sciences

• Sueyoshi Akihiro

  Departments Of Pathology And Radiation Oncology Ucla Center For The Health Sciences:(present Address

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