<Originals>In Vivo Study Factors Concerning Variations of Blood Serotonin Concentration Induced from Repeated Cardiac Puncture

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概要

• 論文の詳細を見る

• Serotonin concentration in blood has wide significance in such fields as medicine and neuropsychiatry. It is hypothesized that if a relationship exists between serotonin concentration and blood cell variations, an attempt to manipulate the cardiac function may clarify the figure of the relationship. A cardiac puncture technique was developed for this purpose and experiments were designed to compare correlation factors between once and twice a week sampling groups. Eight male Sprague-Dawley rats averaging 184g were assigned to one of these two groups. The time-course changes of repeated cardiac puncture reveal an initial fall, a compensational increase and decompensation stage. The initial responses for cardiac puncture appear as platelet counts decrease, especially a lowered heavy platelet population and reduced serotonin level at the third trial of the once a week group and the fifth trial of the twice a week groups. Macrocytic anemia following acute respiratory acidosis is observed in the initial fall of the once a week group. The initial fall was followed by rebound increases in platelet counts, heavy platelet population and increased serotonin and HIAA concentrations and erythrocyte counts. These compensational elevations are accompanied by strong alkalosis peaking at the 5th trial. But all of the increased values fell again at the 6th trial. The time-course changes are discussed in view of "platelet trigger" on serotonin level which consequently affected the anemia and acid-base balance. Histological structure and corticosterone levels revealed functional disturbance of myocardia.

• 近畿大学の論文
• 1984-06-28

著者

• Tomura Takanori

  Department of Biochemistry, Kinki University School of Medicine

• Tomura Takanori

  Department Of Biochemistry & Oncology Kinki University School Of Medicine

• Tomura Takanori

  Department Of Pathology Ucla School Of Medicine The Center For The Health Sciences : (present Addres

• SAKUMA Moto

  Department of Psychiatry, School of Medicine, Wayne State University

• Sakuma Moto

  Department Of Psychiatry School Of Medicine Wayne State University

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• In Vivo Study Factors Concerning Variations of Blood Serotonin Concentration Induced from Repeated Cardiac Puncture
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