Effect of Moisture on Impact Toughness of Sugar-Coated Tablets Manufactured by the Dusting Method
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概要
- 論文の詳細を見る
The purpose of this study was to clarify the effect of moisture on the impact toughness of sugar-coated tablets manufactured by the dusting method. We demonstrated that moisture plays an important role in the impact toughness of sugar-coated tablets. Moisturizing the sugar-coating layer resulted in enhancement of impact toughness of sugar-coated tablets, while reducing moisture in the sugar-coating layer resulted in weakening of the impact toughness. This was due to the characteristics of sucrose, the main ingredient of the sugar-coating layer, which is a soft and non-fragile material at high moisture levels, but hard and fragile at low moisture levels. We also demonstrated that friability as an indicator of impact toughness changed with time, and friability should be measured at 14 d after manufacture. This is due to moisture movement from outer sugar-coating layer into the inner sugar-coated tablets. Incorporating microcrystalline cellulose (MCC) in the subcoating layer resulted in sugar-coating layers with high resistance against impact even though moisture content of sugar-coated tablets was low. We confirmed the high impact toughness of the sugar-coated tablets with MCC whose moisture content was low from the results of both free fall and friability tests. We suggest that the dusting method using dusting powder containing MCC is a useful method for the production of sugar-coated tablets containing moisture sensitive drugs.
- 公益社団法人日本薬学会の論文
- 2004-03-01
著者
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OHNO Yasuo
Institute of Technology and Science, The University of Tokushima
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Ohno Y
National Inst. Health Sci. Tokyo Jpn
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Ohmori S
Healthcare Research Laboratories Consumer Healthcare Company Takeda Chemical Industries Ltd.
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Ohmori S
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Ohmori Shinji
Healthcare Research Laboratories Consumer Healthcare Company Takeda Chemical Industries Ltd.
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Makino Taketoshi
R&d Division Sunstar Inc.
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Ohno Y
Department Of Pharmacology College Of Pharmacy Nihon University
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OHNO Yasuo
Healthcare Research Laboratories, Consumer Healthcare Company, Takeda Chemical Industries, Ltd.
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MAKINO Tadashi
Healthcare Research Laboratories, Consumer Healthcare Company, Takeda Chemical Industries, Ltd.
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KASHIHARA Toshio
Healthcare Research Laboratories, Consumer Healthcare Company, Takeda Chemical Industries, Ltd.
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Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Makino Tadashi
Healthcare Research Laboratories Consumer Healthcare Company Takeda Chemical Industries Ltd.
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Makino Toshiaki
R&d Division Sunstar Inc.
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Kashihara Toshio
Healthcare Research Laboratories Consumer Healthcare Company Takeda Chemical Industries Ltd.
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OHNO Yasuo
Health Sciences, Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences
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