Liposomalization of Lactoferrin Enhanced It's Anti-inflammatory Effects via Oral Administration(Biopharmacy)
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概要
- 論文の詳細を見る
It is known that lactoferrin is one of the functional proteins contained in mammalian milk and that it plays an important role in the immune system. In this study, we prepared multi-lamellar liposomal bovine lactoferrin composed of egg yolk phosphatidylcholine and phytosterol for oral delivery, and examined any resulting anti-in-flammatory effects. Oral pretreatment of liposomal lactoferrin exhibited more suppressive effects than did nonliposomal lactoferrin on CCl_4-induced hepatic injury in rats as well as on lipopolysaccharide-induced TNF-alpha production from mouse peripheral blood mononuclear leukocytes. Further investigation revealed that the liposomalization did not exert influence on the absorbability of lactoferrin to the venous blood or lymph following an intraduodenal administration in rats. Furthermore, there was no significant difference exhibited between the antigenicity of liposomal and non-liposomal lactoferrin, which was measured using the passive cutaneous anaphylaxis reaction following oral sensitization to them in guinea pigs. These results suggest that liposomal lactoferrin might act more effectively than conventional lactoferrin in the intestinal site, which is regarded as an active site of orally administered lactoferrin, although the biological mechanism is not fully understood yet. Consequently we propose that liposomal lactoferrin could be a novel active constituent useful for preventive and therapeutic treatment of inflammatory diseases.
- 2005-09-01
著者
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TAKEUCHI Takashi
Department of Pediatrics, Wakayama Medical University
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ISHIKADO Atsushi
R&D Center, Sunstar Inc.
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IMANAKA Hiromichi
R&D Center, Sunstar Inc.
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HARADA Etsumori
Department of Veterinary Physiology, Faculty of Agriculture, Tottori University
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MAKINO Taketoshi
R&D Center, Sunstar Inc.
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Harada Etsumori
Department Of Physiology Faculty Of Veterinary Medicine Hokkaido University
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Ishikado Atsushi
R&d Division Sunstar Inc.
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Makino Taketoshi
R&d Division Sunstar Inc.
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Imanaka Hiromichi
Department Of Medical Biochemistry Graduate School Of Pharmaceutical Sciences University Of Shizuoka
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Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Makino Toshiaki
R&d Division Sunstar Inc.
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Makino Taketoshi
R&d Center Sunstar Inc.
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Takeuchi Takashi
Department Of Chemical Engineering Science Yokohama National University
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Takeuchi Takashi
三菱化成生命科学研究所
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Takeuchi Takashi
Department of Pathology, Division of Molecular Pathology, National University Corporation, Ehime University School of Medicine
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