Two-week feeding of difructose anhydride III enhances calcium absorptive activity with epithelial cell proliferation in isolated rat cecal mucosa

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概要

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• ObjectiveIngestion of difructose anhydride III (DFAIII) enhances calcium (Ca) absorption in rats. The present study investigated the mechanism involved in increased Ca transport by DFAIII ingestion. The short-term and long-term effects of DFAIII feeding on Ca transport were determined by using isolated epithelium from the small and large intestine in rats.MethodsMale Sprague-Dawley rats were fed an 8% cellulose or 5% cellulose plus 3% DFAIII diet for 14 d. Net epithelial Ca transport in the small intestine, cecum, and colon was compared between the two diet groups by using an Ussing chamber. The contents and epithelial tissues in the cecum were analyzed.ResultsThere were no differences in basal and luminal DFAIII-induced Ca transport in the isolated small intestinal and colonic mucosa between the two diet groups. Basal and lumen DFAIII-induced Ca transport in the cecum in the DFAIII-fed group was higher than that in the control group. A decrease in pH and an increase in Ca pools, short-chain fatty acids, or organic acids in the cecal contents and in the depth and number of cells in crypts in cecal tissue were observed.ConclusionsThe increase in Ca transport involved two mechanisms: the presence of DFAIII in the small intestine directly affected the epithelial tissue and caused increased Ca absorption as a short-term effect, and the degradation of DFAIII by microbial fermentation produced short-chain fatty acids and subsequently enhanced Ca absorption in the large intestine as a long-term effect.

• Elsevierの論文

著者

• SHIGEMATSU Norihiro

  FANCL Business Development Headquarters, Preventive Healthcare Division

• 冨田 房男

  北海道大学農学部

• 冨田 房男

  Hokkaido Study Center The University Of Air

• Tomita Fusao

  Hokkaido University:hokkaido Study Center University Of The Air

• Tomita Fusao

  Laboratory Of Applied Microbiology

• Tomita Fusao

  Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University

• Tomita Fusao

  Department Of Agricultural Biochemistry Faculty Of Agriculture Hokkaido University

• Tomita Fusao

  Laboratory Of Applied Microbiology Department Of Bioscience And Chemistry Faculty Of Agriculture Hok

• Hara H

  Lab. Of Nutritional Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido

• Amano Midori

  Northern Advancement Center For Science & Technology

• Chiji Hideyuki

  Department Of Food Science And Human Nutrition Faculty Of Human Life Science Fuji Women's Unive

• Shigematsu Norihiro

  Res. Inst. Fancl Co.

• Shigematsu N

  Fancl Co. Yokohama Jpn

• Hara Hiroshi

  Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.

• Mineo Hitoshi

  Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido Univ. Kita-9 Nishi-9 Sapporo Hokk

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