Prevention of Aberrant Crypt Foci Formation by Dietary Maize and Yeast Cerebrosides in 1, 2-Dimethylhydrazine-treated Mice

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概要

• 論文の詳細を見る

• For clarification of physiological effects of dietary maize and yeast sphingolipids on colon cancer in vivo, we investigated the effects of dietary maize and yeast cerebrosides on 1,2-dimethylhydrazine (DMH) -induced aberrant crypt foci (ACF) formation in mouse large intestine. After 10 weeks of maize and yeast cerebroside feeding and DMH administration, DMH-induced ACF formation was significantly suppressed in all large intestines of these mice. When lipids in the feces of mice fed maize and yeast cerebrosides were analyzed, maize and yeast cerebrosides decomposed by intestinal enzyme and/or microflora were observed. The present study demonstrated that DMH-induced ACF formation could be inhibited in mouse large intestine by maize and yeast cerebrosides. Daily ingestion of these compounds may serve to suppress colon carcinoma in humans.

• 日本油化学会の論文
• 2005-01-01

著者

• Ohnishi Masao

  Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine

• Ohnishi M

  Obihiro Univ. Agriculture And Veterinary Medicine Obihiro Jpn

• Ohnishi Masao

  Dep. Of Agricultural And Life Sci. Obihiro Univ. Of Agriculture And Veterinary Medicine

• Ohnishi M

  Department Of Agricultural And Life Sciences Obihiro University Of Agriculture And Veterinary Medici

• Kinoshita Mikio

  Department of Orthodontics, Osaka Dental University

• KASHIMA Minoru

  NOF Corporation

• ONO Jisaburo

  CENTRAL LABORATORY NIPPON FLOUR MILLS CO., LTD.

• Ohnishi M

  Iwate Univ. Iwate Jpn

• Ohnishi Masao

  Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin

• Kojima Michiyuki

  Department Of Bioresource Chemistry Obihiro University Of Agriculture And Veterinary Medicine

• Kondo Maki

  Dept. Cell Biol. Nat. Inst. Basic Biol.

• AIDA KAZUHIKO

  Department of Applied Biological Chemistry, Faculty of Agiculture, Niigata University

• Tamura Masahiko

  Nippon Beet Sugar Mfg. Co. Ltd.

• TANJI Mikio

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici

• SUGAWARA Tatsuya

  Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University

• TAMURA Masahiko

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici

• UENO Norimichi

  Central Laboratory, Nippon Flour Mills Co., Ltd.

• Tanji M

  Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin

• Ueno Norimichi

  Central Laboratory Nippon Flour Mills Co. Ltd.

• Kinoshita Mikio

  Dep. Of Agricultural And Life Sci. Obihiro Univ. Of Agriculture And Veterinary Medicine

• Ohnishi M

  Laboratory Of Applied Bioscience Obihiro University Of Agriculture And Veterinary Medicine

• Aida Kazuhiko

  Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University

• Sugawara Tatsuya

  Div. Of Applied Biosciences Graduated School Of Agriculture Kyoto Univ.

• ONO Jisaburo

  Nippon Flour Mills Co., Ltd., Central Laboratory

• Aida Kazuhiko

  Nippon Flour Mills Co. Ltd. Central Laboratory

• Sugawara Tatsuya

  Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University

• Kinoshita Mikio

  Department Of Agricultural And Life Sciences Obihiro University Of Agriculture And Veterinary Medici

• Komai Michio

  Nof Corporation

• Ono Jisaburo

  Nippon Flour Mills Co. Ltd. Central Laboratory

• KINOSHITA Mikio

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine

• AIDA Kazuhiko

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine

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