Apoptosis Inducement by Plant and Fungus Sphingoid Bases in Human Colon Cancer Cells
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概要
- 論文の詳細を見る
In the present study, examination was made of the apoptosis-inducing activity of sphingoid bases from plant and fungus sphingolipids and the mechanisms involved. Sphingoid bases from maize and lactic yeast, Kluyveromyces lactis (trans-4, trans-8-sphingadienine, trans-4, cis-8-sphingadienine and 9-methyl-trans-4, trans-8-sphingadienine) were found to bring about apoptosis in Caco-2 human colon cancer cells. The apoptosis-inducing activity of trans-4, cis-8-sphingadienine and 9-methyl-trans-4, trans-8-sphingadienine was significantly higher than that of trans-4-sphingenine. In differentiated Caco-2 cells, the model for normal intestine cells, no apoptosis by sphingoid bases was noted to occur. The Caspase-3 inhibitor suppressed sphingoid base-induced apoptosis in Caco-2 cells, thus indicating activation of the caspase pathway to be related to sphingoid base-induced apoptosis in Caco-2 cells. Sphingoid bases from plants and fungi caused intracellular β-catenin content to decrease, as was also noted in the case of sphingosine and sphinganine from animal tissues. It would thus appear that sphingolipids in edible plants and fungi may be considered functional lipids and the apoptosis-inducing pathway by sphingoid bases may be related to signal transduction via β-catenin.
- 日本油化学会の論文
- 2004-10-01
著者
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Ohnishi M
Obihiro Univ. Agriculture And Veterinary Medicine Obihiro Jpn
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Ohnishi Masao
Dep. Of Agricultural And Life Sci. Obihiro Univ. Of Agriculture And Veterinary Medicine
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Ohnishi M
Department Of Agricultural And Life Sciences Obihiro University Of Agriculture And Veterinary Medici
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Miyazawa Teruo
Biodynamic Chemistry Graduate School Of Life Sci. And Agriculture Tohoku Univ.
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Miyazawa T
Tohoku Univ. Miyagi Jpn
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Miyazawa T
Tohoku Univ. Sendai Jpn
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Miyazawa Teruo
Department Of Food Chemistry Faculty Of Agriculture Tohoku University
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MIYAZAWA Teruo
Laboratory of Biodynamic Chemistry, Graduate School of Life Science and Agriculture, Tohoku Universi
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KASHIMA Minoru
NOF Corporation
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ONO Jisaburo
CENTRAL LABORATORY NIPPON FLOUR MILLS CO., LTD.
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Ohnishi M
Iwate Univ. Iwate Jpn
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Kojima Michiyuki
Department Of Bioresource Chemistry Obihiro University Of Agriculture And Veterinary Medicine
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Miyazawa Teruo
Laboratory Of Biodynamic Chemistry Graduate School Of Life Science And Agriculture Tohoku University
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Kondo Maki
Dept. Cell Biol. Nat. Inst. Basic Biol.
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Miyazawa Teruo
Tohoku Univ.
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SUGAWARA Tatsuya
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
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Kinoshita Mikio
Dep. Of Agricultural And Life Sci. Obihiro Univ. Of Agriculture And Veterinary Medicine
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Ohnishi M
Laboratory Of Applied Bioscience Obihiro University Of Agriculture And Veterinary Medicine
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AIDA Kazuhiko
The United Graduate School of Agricultural Sciences, Iwate University
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KINOSHITA Mikio
The United Graduate School of Agricultural Sciences, Iwate University
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OHNISHI Masao
The United Graduate School of Agricultural Sciences, Iwate University
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Sugawara Tatsuya
Div. Of Applied Biosciences Graduated School Of Agriculture Kyoto Univ.
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ONO Jisaburo
Nippon Flour Mills Co., Ltd., Central Laboratory
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Aida Kazuhiko
Nippon Flour Mills Co. Ltd. Central Laboratory
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Sugawara Tatsuya
Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University
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Komai Michio
Nof Corporation
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Ono Jisaburo
Nippon Flour Mills Co. Ltd. Central Laboratory
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Masuko Tsuyoshi
Department Of Surgery Division Gi And Colorectal Surgery Research Unit Of Biological Regulation And
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Masuko Tsuyoshi
Department Of Surgery Tohoku University Graduate School Of Medicine
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OHNISHI Masao
The United Graduate School of Agricultural Science, Iwate University
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KINOSHITA Mikio
The United Graduate School of Agricultural Science, Iwate University
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MIYAZAWA Teruo
Laboratories of 1 Food & Biodynamic Chemistry Tohoku University
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