Dose-dependent Incorporation of Tea Catechins, (-)-Epigallocatechin-3-gallate and (-)-Epigallocatechin, into Human Plasma
スポンサーリンク
概要
- 論文の詳細を見る
Tea catechins, (-)-epigallocatechin-3-gallate (EGCg) and (-)-epigallocatechin (EGC), have been reported to suppress oxidation of plasma low density lipoprotein (LDL) in vitro. If dietary catechins can be efficiently incorporated into human blood plasma, anti-atherosclerotic effects in preventing oxidative modification of LDL would be expected. In this study, a newly developed chemiluminescence detection-high pressure liquid chromatography (CL-HPLC) method for measuring plasma catechins was used and the incorporation of EGCg and EGC into human plasma was investigated. Healthy subjects orally ingested 3, 5, or 7 capsules of green tea extract (corresponding to 225, 375, and 525 mg EGCg and 7.5, 12.5, and 17.5mg EGC, redpectively). The plasma EGCg and EGC concentrations before the administration were all below the detection limit (< 2 pmol/ml), but 90 min after, significantly and dose-dependently increased to 657, 4300, and 4410 pmol EGCg/ml, and 35, 144, and 255 pmol EGC/ml, in the subjects who received 3, 5, and 7 capsules, respectively. Both EGCg and EGC levels detected in plasma corresponded to 0.2-2.0% of the ingested amount. Catechin intake had no effect on the basal level of endogenous antioxidants (α-tocopherol, β-carotene, and lycopene) or of lipids in plasma. These results suggested that drinking green tea daily would contribute to maintain plasma catechin levels sufficient to exert antioxidant activity against oxidative modification of lipoproteins in blood circulation systems.
- 社団法人日本農芸化学会の論文
- 1997-12-23
著者
-
NAKAGAWA Kiyotaka
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
-
MIYAZAWA Teruo
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
-
Miyazawa Teruo
Food & Biodynamic Chemistry Laboratory Graduate School Of Life Science And Agriculture Tohoku Un
-
Okuda Shiho
Food Chemistry Laboratory Faculty Of Agriculture Tohoku University
-
Nakagawa Kiyotaka
Food & Biodynamic Chemistry Laboratory Graduate School Of Life Science And Agriculture Tohoku Un
-
Miyazawa Teruo
Food Chemistry Laboratory Faculty Of Agriculture Tohoku University
-
Nakagawa Kiyotaka
Food Chemistry Laboratory Faculty Of Agriculture Tohoku University
関連論文
- Cryptococcus neoformans inhibits nitric oxide synthesis caused by CpG-oligodeoxynucleotide-stimulated macrophages in a fashion independent of capsular polysaccharides
- Optimization of 1-Deoxynojirimycin Extraction from Mulberry Leaves by Using Response Surface Methodology
- Anti-Angiogenic Effects of Conjugated Docosahexaenoic Acid in Vitro and in Vivo
- Current Topics in Food and Biodynamic Chemistry Research
- Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma: Application to Pharmacokinetic Studies
- Distribution of Tocotrienols in Rats Fed a Rice Bran Tocotrienol Concentrate
- Recommended Methods of Fatty Acid Methylester Preparation for Conjugated Dienes and Trienes in Food and Biological Samples
- Anti-angiogenic Activity of Tocotrienol(Food & Nutrition Science)
- Effects of Co-Administration of Tea Epigallocatechin-3-gallate (EGCG) and Caffeine on Absorption and Metabolism of EGCG in Humans
- Tocotrienol Content in Hen Eggs: Its Fortification by Supplementing the Feed with Rice Bran Scum Oil
- Anthocyanin Administration Elevates Plasma Homocysteine in Rats
- Dose-dependent Incorporation of Tea Catechins, (-)-Epigallocatechin-3-gallate and (-)-Epigallocatechin, into Human Plasma
- Efflux of Sphingoid Bases by P-Glycoprotein in Human Intestinal Caco-2 Cells
- Optimization of 1-Deoxynojirimycin Extraction from Mulberry Leaves by Using Response Surface Methodology
- Effects of Co-Administration of Tea Epigallocatechin-3-gallate (EGCG) and Caffeine on Absorption and Metabolism of EGCG in Humans
- Tocotrienol Content in Hen Eggs : Its Fortification by Supplementing the Feed with Rice Bran Scum Oil
- Anti-Angiogenic Effects of Conjugated Docosahexaenoic Acid in Vitro and in Vivo
- Distribution of Tocotrienols in Rats Fed a Rice Bran Tocotrienol Concentrate
- Erythrocytes Carotenoids after Astaxanthin Supplementation in Middle-Aged and Senior Japanese Subjects
- Plasma Carotenoid Concentrations before and after Supplementation with Astaxanthin in Middle-Aged and Senior Subjects
- Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma : Application to Pharmacokinetic Studies
- Anthocyanin Administration Elevates Plasma Homocysteine in Rats
- Plasma Carotenoid Concentrations before and after Supplementation with Astaxanthin in Middle-Aged and Senior Subjects
- Amyloid β Induces Adhesion of Erythrocytes to Endothelial Cells and Affects Endothelial Viability and Functionality
- Absorption and Distribution of Tea Catechin, (-)-Epigallocatechin-3-Gallate, in the Rat
- Efficient Establishment of Pig Embryonic Fibroblast Cell Lines with Conditional Expression of the Simian Vacuolating Virus 40 Large T Fragment
- Efficient Establishment of Pig Embryonic Fibroblast Cell Lines with Conditional Expression of the Simian Vacuolating Virus 40 Large T Fragment
- Physiological Effects and Tissue Distribution from Large Doses of Tocotrienol in Rats
- γ-Tocotrienol Attenuates Triglyceride through Effect on Lipogenic Gene Expressions in Mouse Hepatocellular Carcinoma Hepa 1-6
- Oxidative Stress during Development of Alcoholic Fatty Liver: Therapeutic Potential of Cacao Polyphenol