Anti-Angiogenic Effects of Conjugated Docosahexaenoic Acid in Vitro and in Vivo
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概要
- 論文の詳細を見る
The anti-angiogenic effects of conjugated docosahexaenoic acid (CDHA), which was prepared by an alkaline treatment of docosahexaenoic acid and contained conjugated double bonds, were investigated in vitro and in vivo. CDHA inhibited tube formation by the bovine aortic endothelial cell (BAEC), and also inhibited the proliferation of BAEC at a concentration of CDHA that suppressed tube formation, but did not influence cell migration. The inhibition of BAEC growth caused by CDHA was accompanied by a marked change in cellular morphology. Nuclear condensation and brightness were observed in Hoechst 33342-stained cells treated with CDHA, indicating that CDHA induced apoptosis in BAEC. We also evaluated the angiogenesis inhibition of CDHA in vivo. The vessel formation which was triggered by tumor cells was clearly suppressed in mice orally given CDHA. Our findings suggest that CDHA has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.
- 社団法人 日本農芸化学会の論文
- 2007-08-23
著者
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MIYAZAWA Teruo
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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Tsuzuki Tsuyoshi
Food & Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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Shibata Akira
Food & Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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Kawakami Yuki
Food & Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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NAKAGAYA Kiyotaka
Food & Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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Kawakami Yuki
Dep. Of Nutritional Sci. Fac. Of Health And Welfare Sci. Okayama Prefectural Univ.
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Miyazawa Teruo
Biodynamic Chemistry Graduate School Of Life Sci. And Agriculture Tohoku Univ.
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Miyazawa T
Tohoku Univ. Miyagi Jpn
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Miyazawa T
Tohoku Univ. Sendai Jpn
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Miyazawa Teruo
Department Of Food Chemistry Faculty Of Agriculture Tohoku University
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Miyazawa Teruo
Food & Biodynamic Chemistry Laboratory Graduate School Of Life Science And Agriculture Tohoku Un
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Nakagawa K
Biodynamic Chemistry Graduate School Of Life Sci. And Agriculture Tohoku Univ.
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Miyazawa Teruo
Tohoku Univ.
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Tsuzuki Tsuyoshi
Food And Biomolecular Science Graduate School Of Life Science And Agriculture Tohoku University
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Shibata Akira
Food & Biodynamic Chemistry Laboratory Graduate School Of Agricultural Science Tohoku University
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Tsuduki Tsuyoshi
Laboratory Of Food And Biomolecular Science Graduate School Of Agriculture Tohoku University
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Masuko Tsuyoshi
Department Of Surgery Division Gi And Colorectal Surgery Research Unit Of Biological Regulation And
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Masuko Tsuyoshi
Department Of Surgery Tohoku University Graduate School Of Medicine
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