Safety of Dietary Conjugated Linoleic Acid (CLA) in a 12-weeks Trial in Healthy Overweight Japanese Male Volunteers
スポンサーリンク
概要
- 論文の詳細を見る
A study was conducted to investigate the short-term safety of dietary conjugated linoleic acid (CLA) in overweight Japanese male volunteers. The study design was a randomized, double-blind placebo-controlled trial including 60 healthy overweight volunteers (body mass index (BMI), 25~35 kg/m2). The subjects were randomly assigned to three groups: 5.4 g CLA-triacylglycerol (3.4 g as CLA), 10.8 g CLA-triacylglycerol (6.8 g as CLA) and placebo (10.8 g safflower oil) daily for 12 weeks. The CLA-triaclyglycerol contained 9c,11t- and 10t,12c-isomers at an equal proportion. The safety was evaluated by analyses of blood parameters and by clinical examinations at the baseline, and at 6 and 12 weeks, including vital signs and adverse effects. All subjects completed the study. The occurrence of adverse events tended to be higher in the CLA groups than in the placebo group, but all of the adverse events were mild to moderate, within normal ranges, and temporary. Serum aspartate aminotransferase (AST) activity did not differ significantly between the groups at 12 weeks, but in the high CLA group it was slightly increased from the baseline. Serum alanine aminotransferase (ALT) activity was higher in the high CLA group than in the placebo group after 12 weeks and was higher than at the baseline in both CLA groups. However, statistical analysis of the population of apparently healthy volunteers who had normal blood parameters at the baseline revealed that AST and ALT levels did not differ significantly among the 3 groups at 12 weeks. Moreover, no clinically significant changes in vital signs were observed in any of the groups. These results indicate that CLA at a dose of 3.4 g/day is a safe dietary level in healthy Japanese populations in terms of the parameters examined.
- 日本油化学会の論文
著者
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岩田 敏夫
リノール油脂
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Kondo Kazuo
Institute Of Environmental Science For Human Life Ochanomizu University
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IWATA Toshio
Research Laboratory, The Nisshin OilliO Group, Ltd.
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KAMEGAI Takeshi
Research Laboratory, The Nisshin OilliO Group, Ltd.
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KASAI Michio
Research Laboratory, Nisshin Oil Mills, Ltd.
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AOYAMA Toshiaki
Research Laboratory, Nisshin Oil Mills, Ltd.
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Iwata Toshio
Research Laboratory The Nisshin Oillio Group Ltd.
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Yamauchi-Sato Yoshie
Research Laboratory, The Nisshin OilliO Group, Ltd.
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Ogawa Akiko
Research Laboratory, The Nisshin OilliO Group, Ltd.
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KASAI Michio
Research Laboratory Nisshin Oil Mills, Ltd.
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Kasai Michio
Research Laboratory, The Nisshin Oillio Group, Ltd.
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AOYAMA Toshiaki
Research Laboratory Nisshin Oil Mills, Ltd.
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Aoyama Toshiaki
Research Laboratory, The Nisshin Oillio Group, Ltd.
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