Dose-Response Study of Daily Cocoa Intake on the Oxidative Susceptibility of Low-Density Lipoprotein in Healthy Human Volunteers
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概要
- 論文の詳細を見る
A four-period crossover study was conducted to evaluate the dose-related response of daily cocoa intake on the oxidative susceptibility of low-density lipoprotein (LDL) in healthy human volunteers. Each supplementation phase consisted of a 14-day feeding period followed by a 28-day washout period. During the period, healthy male volunteers (n=8) ingested 18, 24 or 36 g of cocoa powder per day (1.3, 1.74 or 2.61 g of polyphenols per day). During the control period, these subjects ingested sugar. LDL oxidative susceptibility was measured as the lag time of conjugated diene formation that started with the addition of a radical initiator, 2, 2'-azobis (4-methoxy-2, 4-dimethyl-valeronitrile). Samples were analyzed at pre-, one week, and two weeks post-supplementation. In the 24 and 36 g cocoa powder ingestion period, significant lag time prolongation was observed. We conclude that the ingestion of more than 24 g of cocoa powder per day (1.74 g of polyphenols) clearly protects LDL from oxidation.
- 公益社団法人日本薬学会の論文
- 2004-12-01
著者
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OSAKABE Naomi
Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd.
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KONDO Kazuo
Institute of Environmental Science for Human Life, Ochanomizu University
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Kondo Kazuo
Institute Of Environmental Science For Human Life Ochanomizu University
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Osakabe N
Nutritional Science Center Health And Bioscience Laboratories Meiji Seika Kaisha Ltd.
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Osakabe Naomi
Health And Bioscience Laboratories Meiji Seika Kaisha Ltd.
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Baba Seigo
Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd.
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Yasuda Akiko
Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd.
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Iwamoto Tamami
Institute of Environmental Science for Human Life, Ochanomozu University
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Kamiyama Masumi
Institute of Environmental Science for Human Life, Ochanomozu University
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Tokunaga Takahisa
Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd.
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Baba Seigo
Health And Bioscience Laboratories Meiji Seika Kaisha Ltd.
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Yasuda Akiko
Health And Bioscience Laboratories Meiji Seika Kaisha Ltd.
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Iwamoto Tamami
Institute Of Environmental Science For Human Life Ochanomozu University
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Kamiyama Masumi
Food Processing Technology Division Department Of Food Technology Nagano Prefecture General Industri
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Tokunaga Takahisa
Health And Bioscience Laboratories Meiji Seika Kaisha Ltd.
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Tokunaga Takahisa
Health & Bioscience Laboratories Meiji Seika Kaisha Ltd.
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Kojima Keiichi
Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.
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Kondo Kazuo
Natural/applied Sciences Div. Graduate School Of Humanities And Sciences Ochanomizu Univ.
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Kamiyama Masumi
Institute Of Environmental Science For Human Life Ochanomozu University
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