Effects of Antioxidants on the Oxidative Susceptibility of Low-Density Lipoprotein
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概要
- 論文の詳細を見る
An important event in the pathogenesis of atherosclerosis is believed to be the oxidative modification of low-density lipoprotein (LDL) initiated by a free radical-driven lipid peroxidation process. Vitamin E acts as a lipophilic chain-breaking antioxidant, while water-soluble chain-breaking antioxidants such as vitamin C or uric acid suppress the oxidation of LDL initiated by aqueous radicals. In this study, we established a new method of measuring the lag time of inhibited lipid peroxidation using the lipophilic azo radical initiator V-70: 2-2-azobis(4-methoxy-2, 4-dimethylvaleronitrile) and investigated in vitro the suscepti-bility of LDL to oxidation using this method when lipid- and water-soluble antioxidants were added. When the lipid-soluble antioxidant, vitamin E, was added to LDL, the lag time was extended whereas a higher dose of vitamin E led to a shortened lag time of V-70-induced lipid peroxidation in LDL. These results suggest that vitamin E radicals (tocopheroxyl radicals) act as prooxidants during the autoxidation of LDL. It was also shown that the shortened lag time induced by higher doses of vitamin E was restored when lipid- and water-soluble antioxidants were added simultaneously, which suggests that vitamin E radicals derived from vitamin E are subsequently reduced by vitamin C to regenerate vitamin E. Thus, the interaction between lipid- and water-soluble antioxidants provides an important function in maintaining LDL resistance to oxi-dation.
著者
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IGARASHI Osamu
Institute of Environmental Science for Human Life, Ochanomizu University
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KONDO Kazuo
Division of Clinical Nutrition, National Institute of Health and Nutrition
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Kondo Kazuo
Institute Of Environmental Science For Human Life Ochanomizu University
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Itakura Hiroshige
Division Of Clinical Nutrition National Institute Of Health And Nutrition
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Iwamoto Tamami
Institute Of Environmental Science For Human Life Ochanomozu University
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Igarashi Osamu
Institute Of Environmental Science For Human Life Ochanomizu University
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Kondo Kazuo
Natural/applied Sciences Div. Graduate School Of Humanities And Sciences Ochanomizu Univ.
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HIRANO Reiko
Division of Clinical Nutrition, National Institute of Health and Nutrition
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IWAMOTO Tamami
Division of Clinical Nutrition, National Institute of Health and Nutrition
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Kondo Kazuo
Division Of Chest Surgery Department Of Surgery Aichi Medical University
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ITAKURA Hiroshige
Division of Clinical Nutrition, National Institute of Health and Nutrition
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