Distribution of α-Toc Stereoisomers in Rats

概要

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The distribution of α-tocopherol (α-Toc) stereoisomers in the tissues of rats fed on diets containing different levels of all-rac-α-tocopheryl acetate was determined by a newly revised HPLC method and compared with that of RRR-α-Toc fed rats. By this method, all-rac-α-Toc in the blood and tissues was completely separated into 2R-isomers (one peak) and 2S-isomers (three peaks). The concentrations of the 2R-isomers of α-Toc in the blood and tissues of the rats in the all-rac-α-tocopheryl acetate group were significantly higher than those of the 2S-isomers. In most tissues, the level of 2S-isomers was in order of SRS > (SSS+ SSR)/2 > SRR. In the RRR-α-Toc-fed groups, the concentration of RRR-α-Toc in every tissue depended on the dose of α-Toc. When the concentration of 2R-isomers in the tissues of rats fed on all-rac-α-Toc (100 mg/kg diet)is compared with the concentration of RRR-α-Toc in the tissues of rats fed on RRR-α-Toc (50 mg/kg diet)the concentration of 2R-isomers in every tissue of the former is the same as the RRR-α-Toc concentration of the latter.
社団法人日本農芸化学会の論文
1994-11-23