Metabolism of Arachidonic, Eicosapentaenoic, and Docosahexaenoic Acids in HepG2 Cells and Rat Hepatocytes.
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概要
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The metabolism of arachidonic acid (AA), eicosapenta-enoic acid (EPA), and docosahexaenoic acid (DHA) was examined in HepG2 cells, a human hepatoma cell line, and rat hepatocytes. The AA level in HepG2 cells was lower than in rat hepatocytes and incorporation of AA into HepG2 was also smaller than into rat hepatocytes. Both cells could not increase the level of cellular DHA by the addition of exogenous 22:5 (n-3); whereas, rat hepatocytes, but not HepG2 cells, increased the levels of AA from 20:3 (n-6) and EPA from 20:4 (n-3). In both cells, retroconversion of AA to 20:3 (n-6) occurred, but EPA was not retro-converted to 20:4 (n-3). These results suggested that the levels of AA and DHA in both types of cells, were regulated more severely than EPA and that the activity of fatty acid desaturation might be different between n-6 and n-3 families.
- 財団法人 学会誌刊行センターの論文
著者
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Igarashi Osamu
Institute Of Environmental Science For Human Life Ochanomizu University
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FUJIYAMA-FUJIWARA Yoko
Institute of Environmental Science for Human Life, Ochanomizu University
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UMEDA Rumi
Institute of Environmental Science for Human Life, Ochanomizu University
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