Prognostic Significance of Plasma Osteopontin Levels in Patients Undergoing Percutaneous Coronary Intervention(Ischemic Heart Disease)
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概要
- 論文の詳細を見る
Background Osteopontin (OPN) mRNA is highly expressed in atherosclerotic plaques and plasma OPN levels are high in patients with coronary artery disease and in those with restenosis. OPN-overexpressing transgenic mice show markedly increased neointimal formation after arterial injury. Methods and Results The prognostic significance of the preprocedural plasma OPN level was investigated in 130 patients undergoing percutaneous coronary intervention (PCI). Patients were followed up for restenosis and major adverse cardiovascular events (MACE). At 7±3 months after PCI, angiography was performed again in 91 patients, of whom 40 had restenosis. Between patients with and without restenosis, OPN (492±200 vs 482±224ng/ml) and C-reactive protein (CRP: 0.78 vs 0.70mg/L) levels did not differ. During a 3-year follow-up, MACE occurred in 21 patients, who had higher OPN (586±230 vs 438±195ng/ml) and CRP (1.30 vs 0.70mg/L) levels than those without MACE (P<0.005). Both OPN and CRP levels were independent predictors for MACE. Hazard ratios for MACE were 1.3 (95% confidence interval (CI) 1.1-1.5) for a 100ng/ml increase in OPN and 3.6 (95%CI 1.4-9.3) for CRP>1.0mg/L. Conclusions In patients undergoing PCI, the preprocedural OPN and CRP levels are independent predictors for further cardiovascular events, but not for restenosis.
- 社団法人日本循環器学会の論文
- 2008-12-20
著者
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Nakamura Haruo
National Defense Medical College
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Tanaka Nobukiyo
First Department of Internal Medicine, National Defense Medical College
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Ohsuzu Fumitaka
First Department of Internal Medicine, National Defense Medical College
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NAKAMURA Haruo
First Department of Internal Medicine,National Degense Medical College
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Momiyama Yukihiko
National Defense Medical College
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Ohmori Reiko
National Defense Medical College
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Taniguchi Hiroaki
National Defense Medical College
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Kato Ryuichi
National Defense Medical College
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Arakawa Koh
Department Of Medicine 1 Division Of Cardiology National Defense Medical College
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Arakawa Koh
Department Of Cardiology National Defense Medical College
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Ohmori Reiko
Faculty Of Education Utsunomiya University
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Taniguchi Hiroaki
First Department of Internal Medicine, National Defense Medical College
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Ohsuzu Fumitaka
Department Of Internal Medicine National Defense Medical College
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Osuzu Fumitaka
First Department Of Internal Medicine National Defence Medical Collage
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Momiyama Yukihiko
Divisions of Internal Medicine Tokyo Saiseikai Central Hospital
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Kato Ryuichi
First Department of Internal Medicine, National Defense Medical College
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Arakawa Koh
First Department of Internal Medicine, National Defense Medical College
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Tanaka Nobukiyo
National Defence Medical College
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Arakawa Kou
The 1st Dept. of Intern. Med.
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Ohsuzu Fumitaka
Department Of Medicine 1 Division Of Cardiology National Defense Medical College
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Nakamura H
National Defense Medical College
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Momiyama Yukihiko
Division Of Cardiology National Hospital Organization Tokyo Medical Center
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Momiyama Yukihiko
First Department Of Internal Medicine National Defence Medical College
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Momiyama Yukihiko
First Department Of Internal Medicine National Defence Medical College Saitama
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Ohsuzu Fumitaka
First Department Of Internal Medicine National Defence Medical Collage
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Katoh Ryuichi
First Department Of Internal Medicine National Defense Medical College
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Nakamura Haruo
1st Department Of Medicine National Defense Medical College
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Ohsuzu Fumitaka
1st Department Of Medicine National Defense Medical College
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Ohsuzu Fumitaka
First Department Of Internal Medicine And The First Department Of Anatomy National Defense Medical C
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Arakawa Kou
First Department Of Internal Medicine National Defense Medical College
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Arakawa Koh
Internal Medicine I National Defense Medical College
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Nakamura Haruo
1st Department Of Internal Medicine National Defense Medical College
-
Nakamura Haruo
First Department Of Internal Medicine National Defence Medical Collage
-
Arakawa Ko
Department Of Medicine 1 National Defense Medical College
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Arakawa Koh
First Department Of Internal Medicine National Defense Medical College
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Ohsuzu Fumitaka
National Defense Medical College Department Of Internal Medicine-i
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Ohsuzu Fumitaka
National Defense Medical College Internal Medicine-1
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