Polymorphism of the 3'-Untranslated Region of Interleukin-12 p40 Gene is not Associated With the Presence or Severity of Coronary Artery Disease
スポンサーリンク
概要
- 論文の詳細を見る
Background Interleukin (IL)-12 is thought to play an important role in the development of atherosclerosis and recently, polymorphism of the 3'-untranslated region of the IL-12 p40 gene (A1188C) was reported to be associated with diabetes and multiple sclerosis. However, the association between this genetic polymorphism and coronary artery disease (CAD) has not been studied. Methods and Results The frequency of this polymorphism was investigated in 555 patients undergoing coronary angiography: 395 had CAD, of whom 161 also had a myocardial infarction (MI). With regard to the IL-12 p40 polymorphism, 125 had the A/A, 268 had the A/C, and 162 had the C/C genotype. The prevalence of CAD did not differ among the groups (71%, 73%, and 69%, respectively; p=NS). The prevalence of MI was also similar among the groups (28%, 27%, and 33%, respectively; p=NS). Moreover, the number of >50% stenotic vessels, >50% stenotic segments, and ≤50% stenotic segments did not differ among the 3 groups. Conclusions Polymorphism of IL-12 p40 gene was not found to be associated with the presence or severity of CAD, suggesting that it does not play an important role in the development of this disease.
- 社団法人日本循環器学会の論文
- 2005-06-20
著者
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EGASHIRA Tohru
Department of Advanced Technology and Development, BML, Inc.
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NAGANO MAKOTO
Department of Gene Science, BML, Inc.
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Egashira Tohru
Department Of Advanced Technology And Development
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Nakamura Haruo
National Defense Medical College
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Nakamura Haruo
Mitsukoshi Health And Welfare Foundation
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Ohsuzu Fumitaka
First Department of Internal Medicine, National Defense Medical College
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Momiyama Yukihiko
National Defense Medical College
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Ohmori Reiko
National Defense Medical College
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Taniguchi Hiroaki
National Defense Medical College
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Momiyama Yukihiko
First Department of Internal Medicine, National Defence Medical College,Saitama
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Kato Ryuichi
National Defense Medical College
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Ohmori Reiko
First Department Of Internal Medicine National Defense Medical College
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Nagano Makoto
Department Of Advanced Medical Technology And Development Bml Inc.
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Taniguchi Hiroaki
First Department of Internal Medicine, National Defense Medical College
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Ohsuzu Fumitaka
Department Of Internal Medicine National Defense Medical College
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Osuzu Fumitaka
First Department Of Internal Medicine National Defence Medical Collage
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Kato Ryuichi
First Department of Internal Medicine, National Defense Medical College
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Nakamura H
National Defense Medical College
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Momiyama Yukihiko
Division Of Cardiology National Hospital Organization Tokyo Medical Center
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Momiyama Yukihiko
First Department Of Internal Medicine National Defence Medical College
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Momiyama Yukihiko
First Department Of Internal Medicine National Defence Medical College Saitama
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Ohsuzu Fumitaka
First Department Of Internal Medicine National Defence Medical Collage
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Katoh Ryuichi
First Department Of Internal Medicine National Defense Medical College
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Nakamura Haruo
1st Department Of Medicine National Defense Medical College
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Ohsuzu Fumitaka
First Department Of Internal Medicine And The First Department Of Anatomy National Defense Medical C
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Egashira Tohru
Department Of Advanced Medical Technology And Development Bml Inc.
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Nakamura Haruo
1st Department Of Internal Medicine National Defense Medical College
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Nakamura Haruo
First Department Of Internal Medicine National Defence Medical Collage
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Nagano Makoto
Department Of Advanced Technology And Development
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