Acid Base Changes in Ischemic Myocardium and Intervention with Hypothermia or Bicarbonate : SYMPOSIUM ON PATHOPHYSIOLOGY IN THE EARLY STAGE OF ACUTE MYOCARDIAL INFARCTION AND ITS TREATMENT : 51th Annual Scientific Session of the Japanese Circulation Socie

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概要

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• Effects of ischemia and reperfusion on acid-base changes in relation to myocardial contractility, and the effects of correcting H^+ were studied by lowering PCO_2 or increasing HCO_3^- levels. The hearts were perfused by working heart mode and whole heart ischemia was induced by use of a one way valve followed by myocardial warming (37℃, normothermia), cooling (18℃, hypothermia) or warming plus 2.1 mM NaHCO_3 for 15 min. The hearts were then reperfused for 20 min. Coronary effluent was collected through pulmonary artery cannulation and used for the measurement of acid-base changes. There were close correlations between the decrease in coronary flow and LV pressure, LV dP/dt. Close correlations were also observed between the decline in LV pressure and the rise in PCO_2, H^+, and the decline in HCO_3^-. A highly significant correlation was seen between H^+ and lactate production. Myocardial contractility decreased to the same extent in 3 groups during ischemia, whereas its recovery rate in both the hypothermia and HCO_3^--treated groups were significantly higher than in the normothermia group. The increment of H^+ was significantly less in both the hypothermia and HCO_3^--treated groups than in normothermia. These results indicate that lactate production is the major H^+ producing source and the correction of H^+ could minimize the ischemic insult and at the same time contribute to the reperfusion injury.

• 社団法人日本循環器学会の論文
• 1988-07-20

著者

• Mochizuki Seibu

  Department of Cardiology, The Jikei University School of Medicine

• NAGANO MAKOTO

  Department of Gene Science, BML, Inc.

• Taniguchi Masayuki

  Department of Materials Science and Technology, Niigata University

• Nagano M

  Department Of Medicine Jikei Aoto Hospital

• Nagano Makoto

  Department Of Advanced Medical Technology And Development Bml Inc.

• Seki Shingo

  Department of Internal Medicine, Division of Cardiology, Jikei Univeristy Aoto Hospital

• OZEKI Tomoko

  Department of Nutrition, Tokyo Metropolitan Institute of Gerontology

• Taniguchi Masayuki

  Department Of Medicine The Jikei University School Of Medicine Aoto Hospital

• Mochizuki Seibu

  Department Of Cardiology Jikei University School Of Medicine

• Nagano M

  Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine

• USUI Toshiro

  Department of Medicine,Aoto Hospital,Jikei University School of Medicine

• Seki Shengo

  Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine

• Seki Shingo

  Department Of Aquaculture Faculty Of Agricultrue Kochi University

• Usui Toshiro

  Department Of Medicine Aoto Hospital Jikei University School Of Medicine

• Ozeki Tomoko

  Department Of Clinical Nutrition Faculty Of Comprehensive Rehabilitation Osaka Prefecture College Of

• Ozeki Tomoko

  Department Of Medicine Aoto Hospital The Jikei University School Of Medicine

• Nagano Makoto

  Department Of Internal Medicine Aoto Hospital Jikei University School Of Medicine

• Ishiki Moto-o

  Department of Internal Medicine, Aoto Hospital, Jikei University, School of Medicine

• Ishiki Moto-o

  Department Of Medicine Aoto Hospital Jikei University School Of Medicine

• Ishiki Motoo

  Department Of Internal Medicine Aoto Hospital The Jikei University School Of Medicine

• Taniguchi Masayuki

  Department Of Cardiology Jikei University School Of Medicine Daisan Hospital

• Mochizuki Seibu

  Departement Of Cardiology Jikei University School Of Medicine

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