Altered Myocardial Contractility and Energetics in Hypertrophied Myocardium : 53th Annual Scientific Session of the Japanese Circulation Society

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概要

• 論文の詳細を見る

• Alterations of myocardial contractility and energetics were examined in cardiac hypertrophy induced by different types of cardiac overload. Myocardial contractility was estimated by isometric contraction of isolated left ventricular papillary muscles. Myocardial energetics were assessed from ventricular myosin isoenzyme patterns obtained by pyrophosphate gel electrophoresis. Cardiac hypertrophy was induced by endurance swim-training and sustained pressure-overload by abdominal aortic constriction or volume-overload created by an arteriovenous shunt. In swim-trained hypertrophied myocardium, isometric developed tension (T) and dT/dt_<max> showed a tendency to increase and response of dT/dt_<max> to isoproterenol increased significantly as compared with sedentary rats. Training shifted the left ventricular myosin isoenzyme pattern toward VM-1, which has the highest ATPase activity. In pressure- or volume-overloaded myocardium, dT/dt_<max> decreased significantly and mechanical response to isoproterenol also decreased (or tended to decrease in volume-overloaded hearts) as compared with the respective sham-operated controls. In pressure- or volume-overloaded hearts, left ventricular myosin isoenzyme pattern shifted toward VM-3, which has the lowest ATPase activity. These results indicate that alterations in myocardial contractility, mechanical catecholamine responsiveness and myocardial energetics in hypertrophied myocardium do not always display the same trend, but are greatly influenced by the causes or duration of cardiac overload.

• 社団法人日本循環器学会の論文
• 1990-05-20

著者

• NAGANO MAKOTO

  Department of Gene Science, BML, Inc.

• Nagai Makoto

  Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine

• Nagano M

  Department Of Medicine Jikei Aoto Hospital

• Nagano Makoto

  Department Of Advanced Medical Technology And Development Bml Inc.

• Takeda Nobuakira

  Departmernt of Internal Medicine, Aoto Hospital, Jikei Urtversity

• Ohkubo Tadanori

  Department Of Internal Medicine Aoto Hospital Jikei University

• Takeda Nobuakira

  Department Of Medicine Jikei Aoto Hospital

• Takeda Nobuakira

  Department Of Internal Medicine Aoto Hospital

• Nagano Makoto

  Department Of Internal Medicine Aoto Hospital Jikei University School Of Medicine

• Nakamura Izuru

  Department of Internal Medicine, Aoto Hospital, Jikei University

• Okubo Tadanari

  Department of Internal Medicine, Jikei University, School of Medicine

• Nakamura Izuru

  Department Of Internal Medicine Aoto Hospital Jikei University School Of Medicine

• Okubo Tadanari

  Department Of Internal Medicine Aoto Hospital Jikei University School Of Medicine

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