CONVERSION OF LOW DENSITY LIPOPROTEIN 1 (LDL_1, 1.019 < d < 1.045) TO LOW DENSITY LIPOPROTEIN 2 (LDL_2, 1.045 < d < 1.063) BY HEPATIC TRIGLYCERIDE LIPASE

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The role of lipoprotein lipase and hepatic lipase in the conversion of LDL_1 (1.019<d<1.045) to LDL_2 (1.045<1.063) were investigated on the basis of incubation of ^<125>I-LDL_1 with postheparin plasma (PHP) at NaCl concentrations of both 0.15 M and 1.0 M. Insignificant small increments of radioactivity and apoprotein B specific activity of LDL_2 were observed even when ^<125>I-LDL_1 was incubated with preheparin plasma as the control. When ^<125>I-LDL_1 was incubated with PHP, the LDL_1 radioactivity decreased and the LDL_2 radioactivity increased significantly. The apoprotein B specific activity was also increased in the LDL_2 fraction. One molar NaCl did not inhibit these changes. It is concluded that hepatic triglyceride lipase was the major mediator in the conversion of LDL_1 to LDL_2.
社団法人日本循環器学会の論文
1982-07-20