A Double-blind, Placebo-Controlled Study on the Effects of Mayonnaise Containing Free Plant Sterol on Serum Cholesterol Concentration ; Safety Evaluation for Normocholesterolemic and Mildly Hypercholesterolemic Japanese Subjects
スポンサーリンク
概要
- 論文の詳細を見る
Free plant sterol-supplemented mayonnaise was examined for its capacity to lower serum cholesterol and evaluation was made of its mayonnaise. This evaluation was done via a double-blind, placebo-controlled study using forty-six normocholesterolemic and mildly hypercholesterolemic Japanese persons (total cholesterol ≥ 200 mg/dL) randomly divided into two groups. The plant sterol (PS) (+) group was given 15 g mayonnaise containing 800 mg free PS daily, while the PS (-) group did 15 g mayonnaise daily for 12 weeks. Serum total cholesterol (TC) and low-density lipoprotein (LDL)-C were reduced by 4.3% and 9.2% in the PS (+) group, on completion of the 12-week period. At that time, serum apolipoprotein (Apo) B had been reduced by 3.6% in the PS (+) group, this being significantly more compared to the PS (-) group. Serum remnant-like particle (RLP)-C and Apo E did not change significantly in either groups. Decrease in TC and LDL-C with PS (+) group was greater for the serum TC ≥ 220 mg/dL subjects compared to the TC<220 mg/dL subjects. Serum vitamin A, 25 (OH) vitamin D, and vitamin K1 underwent no change throughout the study. Serum α-tocopherol reduction was the same in the two groups. The PS (+) group showed significant increase in serum β-sitosterol while β-sitosterol remained within normal range throughout the study period. For complete blood count (CBC) and blood biochemistry, all values were normal in the two groups. Free plant sterol-supplemented mayonnaise is thus shown a safe food for reducing serum TC and LDL-C. This mayonnaise should prove applicable for reducing serum LDL-C in mildly hypercholesterolemic persons.
- 日本油化学会の論文
- 2004-02-01
著者
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Homma Yasuhiko
Department Of Internal Medicine Tokai University School Of Medicine
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Homma Yasuhiko
キューピー
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Homma Yasuhiko
Department Of Clinical Health Science Tokai University School Of Medicine
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MASUDA Yasunobu
R&D Division, Q. P. Corporation
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MATSUOKA Ryosuke
R&D Division, Q. P. Corporation
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MARUSHIMA Ranko
R&D Division, Q. P. Corporation
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HASEGAWA Mineo
R&D Division, Q. P. Corporation
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Matsuoka R
R&d Division Q. P. Corporation
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Matsuoka Ryosuke
九州大学
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Masuda Y
R & D Division Q.p. Corporation
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Masuda Yasunobu
キューピー
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Masuda Yasunobu
R&d Div. Q.p. Corp.
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Marushima R
R & D Division Q.p. Corporation
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Marushima Ranko
キューピー
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Marushima Ranko
R&d Division Q.p. Corporation
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Hasegawa M
R & D Division Q.p. Corporation
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Hasegawa Mineo
キューピー
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Hasegawa Mineo
R&d Division Q.p. Corporation
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TAKEUCHI Ayako
R&D Division, Q.P. Corporation
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SAKAMOTO Akane
Soiken Inc.
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HIRATA Hiroshi
Akebono Clinic
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KAJIMOTO Osami
Center for Health Care. Osaka University of Foreign Studies
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Kajimoto Osami
Center For Health Care Osaka University Of Foreign Studies
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Takeuchi Ayako
R&d Division Q.p. Corporation
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Matsuoka Ryosuke
Laboratory Of Nutrition Chemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture
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Masuda Yasunobu
Q. P. Corporation R&d Division
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Homma Yasuhiko
Department of Clinical Health Science, Tokai University School of Medicine
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