The Effects of a Probiotic Milk Product Containing Lactobacillus casei Strain Shirota on the Defecation Frequency and the Intestinal Microflora of Sub-optimal Health State Volunteers : A Randomized Placebo-controlled Cross-over Study
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概要
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Forty healthy individuals with a low defecation frequency were selected, and the effects of intake of a fermented milk beverage that contains Lactobacillus casei strain Shirota (LcS) at 4 × 109 bacteria/bottle for 2 weeks (1 bottle/day) on the defecation frequency and intestinal microflora were evaluated by the placebo-controlled double-blind cross-over scheme. Defecation frequency both in times per week and days per week significantly increased in the LcS beverage period compared with the frequency before the beginning of intake. The differences were more notable in those with a stronger tendency to constipation (frequency of defecation before intake ≤ 4.0 times/week, n=21), and the frequency of defecation in the LcS beverage period was significantly higher than in the placebo period. The stool smell and feeling of completion of voiding improved significantly in the LcS beverage period compared with the placebo period, and in those with a stronger tendency to constipation, the stools were significantly softened compared with the state before intake. The number of bifidobacteria and their percentage in the total number of fecal bacteria in the LcS beverage period increased significantly compared with the levels before intake and were significantly higher than the values in the placebo period. No marked change due to the intake of the LcS beverage was observed in the other components of the microflora, the organic acid contents, stool pH, water content, or contents of putrefactive metabolites. These results suggest that intake of the probiotic fermented milk beverage conditions the intestines by improving the state of bowel movements and stool quality and increasing the fecal population level of bifidobacteria.
- 日本ビフィズス菌センターの論文
- 2006-04-01
著者
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KAWAKAMI Koji
Yakult Central Institute for Microbiological Research
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MAKINO Ikuyo
Yakult Central Institute for Microbiological Research
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Makino Ikuyo
Yakult Central Inst. For Microbiological Res.
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KAJIMOTO Osami
Center for Health Care. Osaka University of Foreign Studies
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Matsumoto Kazumasa
Yakult Central Institute for Microbiological Research
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Takada Toshihiko
Yakult Central Institute for Microbiological Research
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Shimizu Kensuke
Yakult Central Institute for Microbiological Research
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Hirano Koichi
Yakult Honsha Co. Ltd
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Nomoto Koji
Yakult Central Institute for Microbiological Research
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Nomoto Koji
ヤクルト中央研究所
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Kawakami Koji
Yakult Central Inst. Microbiological Res. Tokyo Jpn
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Kajimoto Osami
Soiken Inc. Senri Life Science Center:center For Health Care Osaka University Of Foreign Studies
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Kajimoto Osami
Center For Health Care Osaka University Of Foreign Studies
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YAMAOKA Yoshitaku
Yakult Honsha Co., Ltd.
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KADO Yukiko
Yakult Central Institute for Microbiological Research
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NISHIMURA Akira
Soiken Inc.
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Yamaoka Yoshitaku
Yakult Honsha Co. Ltd.
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Nomoto Koji
Yakult Central Inst. For Microbiological Res. Tokyo Jpn
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YAMAOKA Yoshitaku
Yakult Honsha Co. Ltd
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